USE OF AN EMULSION OF ICI 35868 (PROPOFOL) FOR THE INDUCTION AND MAINTENANCE OF ANAESTHESIA

2,6-Diisopropyl phenol in a fat emulsion formulation (propofol) has been used to supplement 67% nitrous oxide in oxygen anaesthesia in 20 patients premedicated with morphine 0.15 mg kg-1and atropine 0.6 mg, and undergoing body surface surgery. Following an induction dose of propofol 2.5 mg kg-1, the...

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Bibliographic Details
Published in:British journal of anaesthesia : BJA 1985-08, Vol.57 (8), p.736-742
Main Authors: KAY, N.H., UPPINGTON, J., SEAR, J.W., ALLEN, M.C.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Alfaxalone Alfadolone Mixture - pharmacology
Anesthesia, General
Anesthetics - pharmacology
Blood Glucose - analysis
Fat Emulsions, Intravenous - pharmacology
Female
Hemodynamics - drug effects
Humans
Hydrocortisone - blood
Male
Middle Aged
Phenols - pharmacology
Propofol
Thiopental - pharmacology
Time Factors
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Summary:2,6-Diisopropyl phenol in a fat emulsion formulation (propofol) has been used to supplement 67% nitrous oxide in oxygen anaesthesia in 20 patients premedicated with morphine 0.15 mg kg-1and atropine 0.6 mg, and undergoing body surface surgery. Following an induction dose of propofol 2.5 mg kg-1, the mean maintenance dose was 73.4μg kg-1min-1. When compared with 10 patients receiving Althesin to supplement nitrous oxide in oxygen in a similar manner, recovery was considerably faster following propofol. The only major side-effect associated with the use of propofol was pain on injection in nine out of 20 patients. When the patients receiving propofol were compared with a second control group (n = 11) in whom anaesthesia was induced with thiopentone 4 mg kg-1and maintained with 1 % halothane and nitrous oxide in oxygen, the former group showed a significant (P
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/57.8.736