Quantitative D2 Dopamine Receptor PET and Structural MRI Changes in Late-Onset Schizophrenia

Late-onset schizophrenia (LOS) is likely a syndrome of diverse etiology. In a series of related studies, we compared LOS patients with normal controls, elderly patients with early-onset schizophrenia (EOS), and Alzheimer's disease patients, using magnetic resonance imaging (MRI) and neurorecept...

Full description

Saved in:
Bibliographic Details
Published in:Schizophrenia bulletin 1993, Vol.19 (4), p.783-795
Main Authors: Pearlson, Godfrey D., Tune, Larry E., Wong, Dean F., Aylward, Elizabeth H., Barta, Patrick E., Powers, Richard E., Tien, Allen Y., Chase, Gary A., Harris, Gordon J., Rabins, Peter V.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Alzheimer's Disease
Atrophy
Brain - pathology
Brain - physiopathology
Dopamine
Etiology
Female
Geriatric Patients
Human
Humans
Magnetic Resonance Imaging
Male
Mental Status Schedule
Middle Aged
Neural Receptors
Neurocognitive Disorders - diagnosis
Neurocognitive Disorders - physiopathology
Neurocognitive Disorders - psychology
Receptors, Dopamine D2 - physiology
Reference Values
Schizophrenia
Schizophrenia - diagnosis
Schizophrenia - physiopathology
Schizophrenic Psychology
Tomography, Emission-Computed
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Late-onset schizophrenia (LOS) is likely a syndrome of diverse etiology. In a series of related studies, we compared LOS patients with normal controls, elderly patients with early-onset schizophrenia (EOS), and Alzheimer's disease patients, using magnetic resonance imaging (MRI) and neuroreceptor positron emission tomography measures, which had previously been reported to be abnormal in EOS. EOS and LOS patients showed similar MRI changes. LOS drugnaive patients had elevated Bmax (receptor density) values for dopamine D2 receptors compared with age and gender norms, a phenomenon previously reported by our group in young schizophrenia patients.
ISSN:0586-7614
1745-1701
DOI:10.1093/schbul/19.4.783