Major Histocompatibility Complex Genes and Susceptibility to Systemic Lupus Erythematosus in Northern India

Fifty-eight patients with systemic lupus erythematosus (SLE) from Northern India were tissue typed for HLA class I and II antigens. The results revealed an appreciable increase of HLA-DR4 (37.5%) among patients compared with controls (17.9%), P < 0.03. Additionally, haplotype B8-DR3 was encounter...

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Bibliographic Details
Published in:Lupus 1993-10, Vol.2 (5), p.313-314
Main Authors: Mehra, N.K., Pande, Ira, Taneja, Veena, Uppal, S.S., Saxena, S.P., Kumar, A., Malaviya, A.N.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Child
Gene Frequency
Haplotypes - genetics
Haplotypes - immunology
HLA Antigens - genetics
Humans
India - epidemiology
Lupus Erythematosus, Systemic - epidemiology
Lupus Erythematosus, Systemic - genetics
Lupus Erythematosus, Systemic - immunology
Major Histocompatibility Complex
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Summary:Fifty-eight patients with systemic lupus erythematosus (SLE) from Northern India were tissue typed for HLA class I and II antigens. The results revealed an appreciable increase of HLA-DR4 (37.5%) among patients compared with controls (17.9%), P < 0.03. Additionally, haplotype B8-DR3 was encountered frequently in the patient group. The findings suggest an important role of MHC genes in influencing susceptibility to SLE.
ISSN:0961-2033
1477-0962
DOI:10.1177/096120339300200506