The tRNA cycle and its relation to the rate of protein synthesis

With the aid of a kinetic model, we have investigated how the adaptation between the various components of the tRNA cycle and the codon frequencies affects the rate of protein synthesis. Depending on the relative amounts of total tRNA, synthetase and ribosomes, the optimal correlations vary between...

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Bibliographic Details
Published in:European biophysics journal 1985-06, Vol.12 (2), p.115-119
Main Authors: Liljenström, H, von Heijne, G, Blomberg, C, Johansson, J
Format: Article
Language:English
Subjects:
Codon
Kinetics
Mathematics
Models, Genetic
Protein Biosynthesis
Proteins - genetics
Ribosomes - metabolism
RNA, Transfer - genetics
RNA, Transfer - metabolism
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Summary:With the aid of a kinetic model, we have investigated how the adaptation between the various components of the tRNA cycle and the codon frequencies affects the rate of protein synthesis. Depending on the relative amounts of total tRNA, synthetase and ribosomes, the optimal correlations vary between a situation where all tRNA species are either present in equal amounts or are present in amounts proportional to the square-root of the corresponding codon frequencies, and a situation where the amounts of the different tRNA species present are linearly proportional to the codon frequencies.
ISSN:0175-7571
1432-1017
DOI:10.1007/BF00260434