Disposition of Enantiomers of sultopride in a Human, Rats and Rabbits

Pharmacokinetics of sultopride enantiomers was examined following a single dose in a human, rabbits and rats. Pharmacokinetic profiles were similar between (+)- and (-)-enantiomers of sultopride in human, whereas the serum concentrations of (-)-sultopride were slightly higher than those of (+)-sulto...

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Bibliographic Details
Published in:Biological & pharmaceutical bulletin 1993/11/15, Vol.16(11), pp.1121-1123
Main Authors: KAMIZONO, Ayako, INOTSUME, Nobuo, FUKUSHIMA, Syouji, NAKANO, Masahiro
Format: Article
Language:English
Subjects:
Amisulpride
Animals
Antipsychotic Agents - administration & dosage
Antipsychotic Agents - blood
Antipsychotic Agents - pharmacokinetics
Antipsychotic Agents - urine
Biological and medical sciences
Chromatography, High Pressure Liquid
enantiomer
human
Humans
Injections, Intravenous
Male
Medical sciences
Neuropharmacology
Pharmacology. Drug treatments
Psycholeptics: tranquillizer, neuroleptic
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
rabbit
Rabbits
rat
Rats
Rats, Wistar
Stereoisomerism
stereoselective disposition
Sulpiride - administration & dosage
Sulpiride - analogs & derivatives
Sulpiride - blood
Sulpiride - pharmacokinetics
Sulpiride - urine
sultopride
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Summary:Pharmacokinetics of sultopride enantiomers was examined following a single dose in a human, rabbits and rats. Pharmacokinetic profiles were similar between (+)- and (-)-enantiomers of sultopride in human, whereas the serum concentrations of (-)-sultopride were slightly higher than those of (+)-sultopride after i.v. administration of 50 mg/kg of racemic sultopride to rats and rabbits.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.16.1121