Inhibition of B16-BL6 Melanoma Growth in Mice by Methionine-Enkephalin

The antitumor effect of methionine-enkephalin ([Met]enkephalin) was demonstrated in C57BL/6J mice inoculated with B16-BL6 melanoma cells. Local subcutaneous tumor growth was inhibited with a 50-μg dose daily for 7 or 14 days. The antitumor effect of [Met]enkephalin was inhibited by the administratio...

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Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 1985-08, Vol.75 (2), p.341-344
Main Author: Murgo, A J
Format: Article
Language:English
Subjects:
Animals
Enkephalin, Methionine - antagonists & inhibitors
Enkephalin, Methionine - pharmacology
Male
Melanoma - pathology
Mice
Mice, Inbred C57BL
Naloxone - pharmacology
Neoplasm Transplantation
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Summary:The antitumor effect of methionine-enkephalin ([Met]enkephalin) was demonstrated in C57BL/6J mice inoculated with B16-BL6 melanoma cells. Local subcutaneous tumor growth was inhibited with a 50-μg dose daily for 7 or 14 days. The antitumor effect of [Met]enkephalin was inhibited by the administration of the opioid receptor antagonist naloxone. Naloxone alone had no significant effect on tumor growth.
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/75.2.341