Influence of derivatives of arachidonic and docosohexaenic acids on AMPA receptors in Purkinje neurons and cognitive functions in mice

The effect of derivatives of arachidonic and docosahexaenoic acids on AMPA receptors in Purkinje cells from the rat cerebellum was studied using the patch-clamp electrophysiological method. It was shown that derivatives of arachidonic acid-arachidonoyl dopamine and docosahexaenoic acid-docosahexaeno...

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Bibliographic Details
Published in:Biology bulletin of the Russian Academy of Sciences 2010-06, Vol.37 (3), p.312-315
Main Authors: Grigoriev, V. V, Serkov, I. V, Beznosko, B. K, Ivanova, T. A, Gretskaya, N. M, Bezuglov, V. V, Bachurin, S. O
Format: Article
Language:English
Subjects:
a-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors
Acids
AMPA receptors
and memory
arachidonic acid derivatives
Biochemistry
Biomedical and Life Sciences
Cell Biology
Cognitive ability
docosahexaenoic acid
docosahexaenoyl dopamine
docosahexaenoyl nitroethylene glycol
Ecology
kainic acid (KA)
learning
Life Sciences
Purkinje cells
Purkinje neurons
Short Communications
Zoology
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Summary:The effect of derivatives of arachidonic and docosahexaenoic acids on AMPA receptors in Purkinje cells from the rat cerebellum was studied using the patch-clamp electrophysiological method. It was shown that derivatives of arachidonic acid-arachidonoyl dopamine and docosahexaenoic acid-docosahexaenoyl dopamine and ester of docosahexaenoic acid with ethylene glycol in nanomolar concentrations effectively potentiated the ionic currents caused by activation of AMPA receptors of kainic acid. Ester of docosahexaenoic acid with nitroethylene glycol blocked AMPA receptors, and anandamide (ethanolamide of arachidonic acid) was not effective. A behavioral test showed that docosahexaenoyl dopamine in doses of 0.1-20 mg/kg had no effect on the learning and memory abilities of the animals tested.
ISSN:1062-3590
1608-3059
DOI:10.1134/s1062359010030131