Comparative efficacy of peste des petits ruminants (PPR) vaccines

Peste des petits ruminants (PPR) is a highly contagious, economically important viral disease of sheep and goats with high morbidity and mortality rates. In order to control the disease effectively, highly sensitive diagnostic tests coupled with potent vaccines are important pre-requisites. At prese...

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Bibliographic Details
Published in:Biologicals 2010-07, Vol.38 (4), p.479-485
Main Authors: Saravanan, P., Sen, A., Balamurugan, V., Rajak, K.K., Bhanuprakash, V., Palaniswami, K.S., Nachimuthu, K., Thangavelu, A., Dhinakarraj, G., Hegde, Raveendra, Singh, R.K.
Format: Article
Language:English
Subjects:
Animals
Control programs
ELISA
Goat Diseases - immunology
Goat Diseases - prevention & control
Goat Diseases - virology
Goats
Peste-des-Petits-Ruminants - immunology
Peste-des-Petits-Ruminants - prevention & control
Peste-des-Petits-Ruminants - veterinary
Peste-des-petits-ruminants virus - immunology
Potency and efficacy
PPR vaccines
RT-PCR
Ruminantia
serum neutralization test
Sheep
Sheep Diseases - immunology
Sheep Diseases - prevention & control
Sheep Diseases - virology
Treatment Outcome
Vaccination - methods
Vaccination - standards
Viral Vaccines - administration & dosage
Viral Vaccines - immunology
Viral Vaccines - standards
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Summary:Peste des petits ruminants (PPR) is a highly contagious, economically important viral disease of sheep and goats with high morbidity and mortality rates. In order to control the disease effectively, highly sensitive diagnostic tests coupled with potent vaccines are important pre-requisites. At present, there are three live attenuated PPR vaccines available in India including Sungri 96, Arasur 87 and Coimbatore 97. Indian Veterinary Research Institute (IVRI) Mukteswar developed the PPR Sungri 96 (isolate of goat origin) vaccine; while Tamil Nadu Veterinary and Animal Sciences University (TANUVAS) developed the Arasur 87 (isolate of sheep origin) and Coimbatore 97 (isolate of goat origin). In this study, the potency of these vaccines including a fourth vaccine from Institute of Animal Health and Veterinary Biologicals, Bangalore (IAH&VB) were tested as per the office International des Epizooties (OIE) guidelines by challenge studies in sheep and goats and their efficacies were evaluated using PPR C-ELISA. Potency tests of these vaccines in sheep and goats revealed that three of the vaccines were potent; however, the IAH &VB vaccine was comparatively less potent. The three vaccines could presumably be used for mass vaccination of both sheep and goats while contemplating PPR control program.
ISSN:1045-1056
1095-8320
DOI:10.1016/j.biologicals.2010.02.003