Influence of intermittent normobaric hypoxia during early organogenesis on the development of white rats

The influence of antenatal intermittent normobaric hypoxia during early organogenesis (days 9–10 of intrauterine development) on the physical development, vegetative balance, and antioxidant defense system of 60-day-old rats was studied. Antenatal exposure to intermittent hypoxia resulted in the imp...

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Bibliographic Details
Published in:Biology bulletin of the Russian Academy of Sciences 2008-06, Vol.35 (3), p.315-317
Main Authors: Trofimova, L. K., Graf, A. V., Maslova, M. V., Dunaeva, T. Yu, Krushinskaya, Ya. V., Maklakova, A. S., Bayzhymanov, A. A., Goncharenko, E. N., Sokolova, N. A.
Format: Article
Language:English
Subjects:
Antioxidants
Biochemistry
Biomedical and Life Sciences
Brain
Brief Communications
Cell Biology
Ecology
Heart
Hypoxia
Life Sciences
Organogenesis
Progeny
Superoxide dismutase
Zoology
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Summary:The influence of antenatal intermittent normobaric hypoxia during early organogenesis (days 9–10 of intrauterine development) on the physical development, vegetative balance, and antioxidant defense system of 60-day-old rats was studied. Antenatal exposure to intermittent hypoxia resulted in the impaired physical development of all offspring during the early 15-day postnatal period and caused changes in the vegetative balance of heart regulation, which were differently directed in males and females. Moreover, females that survived antenatal hypoxia had a decreased superoxide dismutase activity in the brain, compared to that in the control rats.
ISSN:1062-3590
1608-3059
DOI:10.1134/S1062359008030138