Synthesis of terminal acetylenes using POCl sub(3) in pyridine as applied to natural triterpenoids

Four new triterpenoids with alkyne moieties have been synthesized by the proposed procedure; among them, 3b,28-dihydroxy-29-norlup-20(30)-yne has demonstrated antiviral activity against papilloma virus and HCV replicon.

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Bibliographic Details
Published in:Mendeleev communications 2010-08, Vol.20 (4), p.234-236
Main Authors: Kazakova, Oxana B, Medvedeva, Natalya I, Tolstikov, Genrikh A, Kukovinets, Olga S, Yamansarov, Emil Y, Spirikhin, Leonid V, Gubaidullin, Aidar T
Format: Article
Language:English
Subjects:
Hepatitis C virus
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Description
Summary:Four new triterpenoids with alkyne moieties have been synthesized by the proposed procedure; among them, 3b,28-dihydroxy-29-norlup-20(30)-yne has demonstrated antiviral activity against papilloma virus and HCV replicon.
ISSN:0959-9436
DOI:10.1016/j.mencom.2010.06.018