Myocardial apoptosis associated with the expression of proinflammatory cytokines during the course of myocardial infarction

To clarify the role of myocardial apoptosis associated with the expression of proinflammatory cytokines in human myocardial infarction (MI), we have analyzed the expression of apoptosis positive for single-stranded DNA (ss-DNA) antibody, tumor necrosis factor (TNF)-α, and interleukin (IL)-8 in 147 s...

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Bibliographic Details
Published in:Modern pathology 2006-04, Vol.19 (4), p.588-598
Main Authors: Akasaka, Yoshikiyo, Morimoto, Noriko, Ishikawa, Yukio, Fujita, Kazuko, Ito, Kinji, Kimura-Matsumoto, Masayo, Ishiguro, Shigeki, Morita, Hiroshi, Kobayashi, Yoshiro, Ishii, Toshiharu
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Analysis of Variance
Antibodies
Antigens, CD - analysis
Antigens, Differentiation, Myelomonocytic - analysis
Apoptosis
Autopsies
cardiomyocyte
Cardiomyocytes
Cytokines
Cytokines - biosynthesis
Female
granulation tissue
Heart attacks
Humans
IL-8
Immunohistochemistry
Interleukin-10 - analysis
Interleukin-8 - analysis
Laboratory Medicine
Male
Medicine
Medicine & Public Health
Middle Aged
Morphology
Myocardial Infarction - metabolism
Myocardial Infarction - pathology
Myocytes, Cardiac - chemistry
Myocytes, Cardiac - pathology
Neutrophils
original-article
Pathology
Severity of Illness Index
TNF-α
Tumor Necrosis Factor-alpha - analysis
Tumor necrosis factor-TNF
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Summary:To clarify the role of myocardial apoptosis associated with the expression of proinflammatory cytokines in human myocardial infarction (MI), we have analyzed the expression of apoptosis positive for single-stranded DNA (ss-DNA) antibody, tumor necrosis factor (TNF)-α, and interleukin (IL)-8 in 147 samples of infarcted myocardial tissue from 65 patients. ss-DNA-positive apoptotic nuclei were found mainly in cardiomyocytes in the border zones and granulation tissue cells in the infarct foci. The ss-DNA index (SI) of cardiomyocytes (average 0.13%) peaked at stage II (established myocardial necrosis), the value being significantly higher than at stages III (macrophage infiltration), IV (granulation formation), and V (scar formation) (P
ISSN:0893-3952
1530-0285
DOI:10.1038/modpathol.3800568