Preparation of liposomes entrapping essential oil from Atractylodes macrocephala Koidz by modified RESS technique

A modified technique of rapid expansion of supercritical solutions (RESS) was applied to incorporate essential oil extracted from Atractylodes macrocephala Koidz into liposomes. In the modified RESS process, both the liposomal materials and the essential oil were dissolved in the mixture of supercri...

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Bibliographic Details
Published in:Chemical engineering research & design 2010-08, Vol.88 (8), p.1102-1107
Main Authors: Wen, Zhen, Liu, Bo, Zheng, Zongkun, You, Xinkui, Pu, Yitao, Li, Qiong
Format: Article
Language:English
Subjects:
Applied sciences
Atractylodes macrocephala Koidz
Chemical engineering
Chemical engineers
Dissolution
Drugs
Entrapment
Essential oil
Ethanol
Ethyl alcohol
Exact sciences and technology
Liposomes
RESS
Self assembly
Supercritical carbon dioxide
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Summary:A modified technique of rapid expansion of supercritical solutions (RESS) was applied to incorporate essential oil extracted from Atractylodes macrocephala Koidz into liposomes. In the modified RESS process, both the liposomal materials and the essential oil were dissolved in the mixture of supercritical carbon dioxide (SC-CO 2)/ethanol and then the solution was sprayed into an aqueous medium through a coaxial nozzle to form liposomes suspension. The encapsulation performance of liposomes could be controlled by changing expansion processing conditions such as pressure, temperature of SC-CO 2 and the amount of ethanol. The entrapment efficiency, drug loading and average particle size of liposomes were found to be 82.18%, 5.18% and 173 nm, respectively, under the optimum conditions of at a pressure of 30 MPa, a temperature of 338 K and a ethanol mole fraction in SC-CO 2 [( x(CH 3CH 2OH)] of 15%. The formed liposomes appeared as double-layered colloidal spheres with a uniform and narrow particle size distribution. The physicochemical properties of liposomes including entrapment efficiency, dissolution rate and stability were complied with the provisions of Chinese pharmacopoeia. All these results indicate that the modified RESS technique is an innovative way for self-assembly of liposomes incorporation of multi-components extracted from Chinese traditional medicines in the SC-CO 2.
ISSN:0263-8762
DOI:10.1016/j.cherd.2010.01.020