Changes in liver stiffness in patients with chronic hepatitis C with and without HIV co-infection treated with pegylated interferon plus ribavirin

Objectives To evaluate the changes in liver stiffness measurement (LSM) in patients infected by hepatitis C virus (HCV) under pegylated interferon (Peg-IFN) plus ribavirin therapy. Methods One hundred and forty-three HCV-infected patients, of whom 97 (68%) were also carrying HIV, who started treatme...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 2010-10, Vol.65 (10), p.2204-2211
Main Authors: Macías, Juan, del Valle, José, Rivero, Antonio, Mira, José A., Camacho, Ángela, Merchante, Nicolás, Pérez-Camacho, Inés, Neukam, Karin, Rivero-Juárez, Antonio, Mata, Rosario, Torre-Cisneros, Julián, Pineda, Juan A.
Format: Article
Language:English
Subjects:
Adult
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral Agents - administration & dosage
Antiviral drugs
Biological and medical sciences
Cohort Studies
Drug therapy
Elasticity
Female
Gastroenterology. Liver. Pancreas. Abdomen
HCV
Hepatitis
Hepatitis C
Hepatitis C virus
Hepatitis C, Chronic - drug therapy
Hepatitis C, Chronic - pathology
HIV
HIV Infections - complications
Human immunodeficiency virus
Human viral diseases
Humans
Infectious diseases
Interferon-alpha - administration & dosage
Liver - pathology
liver fibrosis
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Longitudinal Studies
Male
Medical sciences
Middle Aged
Other diseases. Semiology
Pharmacology
Pharmacology. Drug treatments
Polyethylene Glycols - administration & dosage
Prospective Studies
Recombinant Proteins
Ribavirin - administration & dosage
RNA, Viral - blood
sustained virological response
transient liver elastometry
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Viral hepatitis
Viral Load
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Summary:Objectives To evaluate the changes in liver stiffness measurement (LSM) in patients infected by hepatitis C virus (HCV) under pegylated interferon (Peg-IFN) plus ribavirin therapy. Methods One hundred and forty-three HCV-infected patients, of whom 97 (68%) were also carrying HIV, who started treatment with Peg-IFN/ribavirin were included in this prospective cohort study. The outcome variable of the study was the change in LSM between baseline and the scheduled date for evaluating sustained virological response (SVR). Results The median (Q1–Q3) LSM values at baseline and at the SVR assessment date were 8.1 (6.2–11.6) kPa and 6.8 (5.2–9.8) kPa (P 
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/dkq272