Increased risk of bacterial infection after engraftment in patients treated with allogeneic bone marrow transplantation following reduced-intensity conditioning regimen

A. Shigematsu, S. Yamamoto, J. Sugita, T. Kondo, M. Onozawa, K. Kahata, T. Endo, S. Shiratori, S. Ota, K. Yamaguchi, K. Wakasa, M. Takahata, H. Goto, S. Ito, R. Takemura, J. Tanaka, S. Hashino, M. Nishio, T. Koike, M. Asaka, M. Imamura. Increased risk of bacterial infection after engraftment in pati...

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Published in:Transplant infectious disease 2010-10, Vol.12 (5), p.412-420
Main Authors: Shigematsu, A., Yamamoto, S., Sugita, J., Kondo, T., Onozawa, M., Kahata, K., Endo, T., Shiratori, S., Ota, S., Yamaguchi, K., Wakasa, K., Takahata, M., Goto, H., Ito, S., Takemura, R., Tanaka, J., Hashino, S., Nishio, M., Koike, T., Asaka, M., Imamura, M.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Bacteria
bacterial infection
Bacterial Infections - epidemiology
Bacterial Infections - etiology
Bone marrow transplantation
Bone Marrow Transplantation - adverse effects
Bone Marrow Transplantation - mortality
Catheterization, Central Venous - adverse effects
febrile neutropenia
Female
Graft vs Host Disease - etiology
graft-versus-host disease
Humans
Infection
Male
Middle Aged
reduced-intensity conditioning
Retrospective Studies
Risk Factors
Transplantation Conditioning
Transplantation, Homologous
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Summary:A. Shigematsu, S. Yamamoto, J. Sugita, T. Kondo, M. Onozawa, K. Kahata, T. Endo, S. Shiratori, S. Ota, K. Yamaguchi, K. Wakasa, M. Takahata, H. Goto, S. Ito, R. Takemura, J. Tanaka, S. Hashino, M. Nishio, T. Koike, M. Asaka, M. Imamura. Increased risk of bacterial infection after engraftment in patients treated with allogeneic bone marrow transplantation following reduced‐intensity conditioning regimen.
Transpl Infect Dis 2010: 12: 412–420. All rights reserved : Although bacterial infection is a major cause of death even after reduced‐intensity conditioning (RIC) for allogeneic stem cell transplantation (SCT), little is known about the epidemiology and risk factors. The incidence of bacterial infection in 43 patients who received allogeneic bone marrow transplantation (BMT) using a RIC regimen was compared with that in 68 patients who received BMT  using a myeloablative conditioning regimen, and risk factors for bacterial infection were identified. Before engraftment, incidences of febrile neutropenia (FN) and documented infections (DI) were significantly decreased in RIC patients (FN: 59.5% vs. 89.6%, P
ISSN:1398-2273
1399-3062
DOI:10.1111/j.1399-3062.2010.00560.x