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Treatment of 161 Men with Symptomatic Late Onset Hypogonadism with Long-Acting Parenteral Testosterone Undecanoate: Effects on Body Composition, Lipids, and Psychosexual Complaints
Elderly men may suffer from late-onset hypogonadism (LOH). The long-term effects of long-acting testosterone undecanoate (TU) in a large number of LOH men have not yet been reported. We analyzed the effects of normalization of plasma testosterone (T) in LOH men. The records of 161 men with LOH (base...
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| Published in: | Journal of sexual medicine 2010-11, Vol.7 (11), p.3765-3774 |
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| creator | Permpongkosol, Sompol Tantirangsee, Nakorn Ratana-olarn, Krisada |
| description | Elderly men may suffer from late-onset hypogonadism (LOH). The long-term effects of long-acting testosterone undecanoate (TU) in a large number of LOH men have not yet been reported.
We analyzed the effects of normalization of plasma testosterone (T) in LOH men.
The records of 161 men with LOH (baseline T12 months. The mean duration of treatment was 90.6 weeks (54 to 150 weeks).
Body mass index (BMI), waist circumference, percentage body fat, total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, triglycerides, prostate-specific antigen (PSA), and hematocrit were measured. Further the Aging Male Symptoms' scale (AMS) and the International Index of Erectile Function (IIEF-5 and 15) were scored.
T therapy was associated with a significant decline in waist circumference (P=0.028) and percentage body fat (P |
| doi_str_mv | 10.1111/j.1743-6109.2010.01994.x |
| format | article |
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We analyzed the effects of normalization of plasma testosterone (T) in LOH men.
The records of 161 men with LOH (baseline T<300ng/dL) were reviewed and 100 men had used parenteral TU for >12 months. The mean duration of treatment was 90.6 weeks (54 to 150 weeks).
Body mass index (BMI), waist circumference, percentage body fat, total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, triglycerides, prostate-specific antigen (PSA), and hematocrit were measured. Further the Aging Male Symptoms' scale (AMS) and the International Index of Erectile Function (IIEF-5 and 15) were scored.
T therapy was associated with a significant decline in waist circumference (P=0.028) and percentage body fat (P<0.001), but no change of BMI. Total cholesterol and LDL cholesterol declined significantly (P=0.005 and P=0.024, respectively), with no significant changes of HDL cholesterol and triglycerides. The scores of sub-scales of AMS (psychological, somotovegetative and sexual factors) decreased (P=0.044, P=0.200 and P=0.071, respectively). The mean IIEF-5 (P=0.011) and IIEF-15 scores (P=0.021) improved significantly. Erectile function domain, orgasmic function domain, sexual desire domain, intercourse satisfaction domain, and overall satisfaction domain improved. Median PSA rose from 0.95 (0.640; 1.558) ng/mL to 1.480 (1.015; 2.275) ng/mL (P<0.001), with 11 patients >4ng/mL (4.01–13.21). On biopsy there was no evidence for malignancy. The mean hematocrit level increased significantly from 42.3±3.4% to 47.1±3.8%.
Normalizing serum T in men with LOH resulted in improvement of the metabolic syndrome, mood and sexual functions and appeared acceptably safe. Permpongkosol S, Tantirangsee N, and Ratana-olarn, K. Treatment of 161 men with symptomatic late onset hypogonadism with long-acting parenteral testosterone undecanoate: Effects on body composition, lipids, and psychosexual complaints.</description><identifier>ISSN: 1743-6095</identifier><identifier>EISSN: 1743-6109</identifier><identifier>DOI: 10.1111/j.1743-6109.2010.01994.x</identifier><identifier>PMID: 20807330</identifier><language>eng</language><publisher>Malden, USA: Elsevier Inc</publisher><subject>Adult ; Age Factors ; Aged ; Aged, 80 and over ; Analysis of Variance ; Androgens - adverse effects ; Androgens - blood ; Androgens - therapeutic use ; Body Composition - drug effects ; Body Mass Index ; Health Status Indicators ; Humans ; Hypogonadism - drug therapy ; Hypogonadism - psychology ; Infusions, Parenteral ; International Index of Erectile Function ; Late-Onset Hypogonadism ; Lipids ; Male ; Middle Aged ; Prostate Safety ; Sex Hormone Binding Globulin ; Sexual Dysfunction, Physiological - drug therapy ; Sexual Dysfunction, Physiological - psychology ; Statistics, Nonparametric ; Surveys and Questionnaires ; Testosterone - adverse effects ; Testosterone - analogs & derivatives ; Testosterone - blood ; Testosterone - therapeutic use ; Testosterone Deficiency Syndrome ; Testosterone Undecanoate ; Thai ; Time Factors ; Waist Circumference</subject><ispartof>Journal of sexual medicine, 2010-11, Vol.7 (11), p.3765-3774</ispartof><rights>2010 International Society for Sexual Medicine</rights><rights>2010 International Society for Sexual Medicine.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4654-a8a6f3b49e3017ff8219892ddc7cf5e44ff4a61ad9217158702d0e90ebff28bc3</citedby><cites>FETCH-LOGICAL-c4654-a8a6f3b49e3017ff8219892ddc7cf5e44ff4a61ad9217158702d0e90ebff28bc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1743-6109.2010.01994.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1743-6109.2010.01994.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20807330$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Permpongkosol, Sompol</creatorcontrib><creatorcontrib>Tantirangsee, Nakorn</creatorcontrib><creatorcontrib>Ratana-olarn, Krisada</creatorcontrib><title>Treatment of 161 Men with Symptomatic Late Onset Hypogonadism with Long-Acting Parenteral Testosterone Undecanoate: Effects on Body Composition, Lipids, and Psychosexual Complaints</title><title>Journal of sexual medicine</title><addtitle>J Sex Med</addtitle><description>Elderly men may suffer from late-onset hypogonadism (LOH). The long-term effects of long-acting testosterone undecanoate (TU) in a large number of LOH men have not yet been reported.
We analyzed the effects of normalization of plasma testosterone (T) in LOH men.
The records of 161 men with LOH (baseline T<300ng/dL) were reviewed and 100 men had used parenteral TU for >12 months. The mean duration of treatment was 90.6 weeks (54 to 150 weeks).
Body mass index (BMI), waist circumference, percentage body fat, total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, triglycerides, prostate-specific antigen (PSA), and hematocrit were measured. Further the Aging Male Symptoms' scale (AMS) and the International Index of Erectile Function (IIEF-5 and 15) were scored.
T therapy was associated with a significant decline in waist circumference (P=0.028) and percentage body fat (P<0.001), but no change of BMI. Total cholesterol and LDL cholesterol declined significantly (P=0.005 and P=0.024, respectively), with no significant changes of HDL cholesterol and triglycerides. The scores of sub-scales of AMS (psychological, somotovegetative and sexual factors) decreased (P=0.044, P=0.200 and P=0.071, respectively). The mean IIEF-5 (P=0.011) and IIEF-15 scores (P=0.021) improved significantly. Erectile function domain, orgasmic function domain, sexual desire domain, intercourse satisfaction domain, and overall satisfaction domain improved. Median PSA rose from 0.95 (0.640; 1.558) ng/mL to 1.480 (1.015; 2.275) ng/mL (P<0.001), with 11 patients >4ng/mL (4.01–13.21). On biopsy there was no evidence for malignancy. The mean hematocrit level increased significantly from 42.3±3.4% to 47.1±3.8%.
Normalizing serum T in men with LOH resulted in improvement of the metabolic syndrome, mood and sexual functions and appeared acceptably safe. Permpongkosol S, Tantirangsee N, and Ratana-olarn, K. Treatment of 161 men with symptomatic late onset hypogonadism with long-acting parenteral testosterone undecanoate: Effects on body composition, lipids, and psychosexual complaints.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Analysis of Variance</subject><subject>Androgens - adverse effects</subject><subject>Androgens - blood</subject><subject>Androgens - therapeutic use</subject><subject>Body Composition - drug effects</subject><subject>Body Mass Index</subject><subject>Health Status Indicators</subject><subject>Humans</subject><subject>Hypogonadism - drug therapy</subject><subject>Hypogonadism - psychology</subject><subject>Infusions, Parenteral</subject><subject>International Index of Erectile Function</subject><subject>Late-Onset Hypogonadism</subject><subject>Lipids</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prostate Safety</subject><subject>Sex Hormone Binding Globulin</subject><subject>Sexual Dysfunction, Physiological - drug therapy</subject><subject>Sexual Dysfunction, Physiological - psychology</subject><subject>Statistics, Nonparametric</subject><subject>Surveys and Questionnaires</subject><subject>Testosterone - adverse effects</subject><subject>Testosterone - analogs & derivatives</subject><subject>Testosterone - blood</subject><subject>Testosterone - therapeutic use</subject><subject>Testosterone Deficiency Syndrome</subject><subject>Testosterone Undecanoate</subject><subject>Thai</subject><subject>Time Factors</subject><subject>Waist Circumference</subject><issn>1743-6095</issn><issn>1743-6109</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNqNkc1u1DAURiMEoqXwCsg7Ns1g5z9ILNppaUFpO6hTsbQ89vXUQ2KntodO3osHxCHtbMEbX8Xn-yznRBEieEbC-riZkTJL44Lgepbg8BWTus5muxfR4f7g5fOM6_wgeuPcBuM0rOR1dJDgCpdpig-j30sLzHegPTISkYKgK9DoUfl7dDt0vTcd84qjhnlAN9qBR5dDb9ZGM6FcN4GN0ev4hHul12jBbOgCy1q0BOeNC7PRgO60AM60CT2f0LmUwL1DRqNTIwY0N11vnPLK6GPUqF4Jd4yYFmjhBn5vHOy2oW-kWqa0d2-jV5K1Dt497UfR3Zfz5fwybm4uvs5PmphnRZ7FrGKFTFdZDSkmpZRVQuqqToTgJZc5ZJmUGSsIE3VCSpJXJU4EhhrDSsqkWvH0KPow9fbWPGzDc2inHIe2ZRrM1tGySJIyq9IskNVEcmucsyBpb1XH7EAJpqMyuqGjDTqaoaMy-lcZ3YXo-6dLtqsOxD747CgAnyfgUbUw_Hcx_XZ7NU4hH095FWTs9nlmf9KiTMuc_ri-oIuz77g5W8zpdeBPJx7Cr_2lwFLHFWgOQtmgjQqj_v2qP2CyzLI</recordid><startdate>201011</startdate><enddate>201011</enddate><creator>Permpongkosol, Sompol</creator><creator>Tantirangsee, Nakorn</creator><creator>Ratana-olarn, Krisada</creator><general>Elsevier Inc</general><general>Blackwell Publishing Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201011</creationdate><title>Treatment of 161 Men with Symptomatic Late Onset Hypogonadism with Long-Acting Parenteral Testosterone Undecanoate: Effects on Body Composition, Lipids, and Psychosexual Complaints</title><author>Permpongkosol, Sompol ; Tantirangsee, Nakorn ; Ratana-olarn, Krisada</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4654-a8a6f3b49e3017ff8219892ddc7cf5e44ff4a61ad9217158702d0e90ebff28bc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Analysis of Variance</topic><topic>Androgens - adverse effects</topic><topic>Androgens - blood</topic><topic>Androgens - therapeutic use</topic><topic>Body Composition - drug effects</topic><topic>Body Mass Index</topic><topic>Health Status Indicators</topic><topic>Humans</topic><topic>Hypogonadism - drug therapy</topic><topic>Hypogonadism - psychology</topic><topic>Infusions, Parenteral</topic><topic>International Index of Erectile Function</topic><topic>Late-Onset Hypogonadism</topic><topic>Lipids</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prostate Safety</topic><topic>Sex Hormone Binding Globulin</topic><topic>Sexual Dysfunction, Physiological - drug therapy</topic><topic>Sexual Dysfunction, Physiological - psychology</topic><topic>Statistics, Nonparametric</topic><topic>Surveys and Questionnaires</topic><topic>Testosterone - adverse effects</topic><topic>Testosterone - analogs & derivatives</topic><topic>Testosterone - blood</topic><topic>Testosterone - therapeutic use</topic><topic>Testosterone Deficiency Syndrome</topic><topic>Testosterone Undecanoate</topic><topic>Thai</topic><topic>Time Factors</topic><topic>Waist Circumference</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Permpongkosol, Sompol</creatorcontrib><creatorcontrib>Tantirangsee, Nakorn</creatorcontrib><creatorcontrib>Ratana-olarn, Krisada</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of sexual medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Permpongkosol, Sompol</au><au>Tantirangsee, Nakorn</au><au>Ratana-olarn, Krisada</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Treatment of 161 Men with Symptomatic Late Onset Hypogonadism with Long-Acting Parenteral Testosterone Undecanoate: Effects on Body Composition, Lipids, and Psychosexual Complaints</atitle><jtitle>Journal of sexual medicine</jtitle><addtitle>J Sex Med</addtitle><date>2010-11</date><risdate>2010</risdate><volume>7</volume><issue>11</issue><spage>3765</spage><epage>3774</epage><pages>3765-3774</pages><issn>1743-6095</issn><eissn>1743-6109</eissn><abstract>Elderly men may suffer from late-onset hypogonadism (LOH). The long-term effects of long-acting testosterone undecanoate (TU) in a large number of LOH men have not yet been reported.
We analyzed the effects of normalization of plasma testosterone (T) in LOH men.
The records of 161 men with LOH (baseline T<300ng/dL) were reviewed and 100 men had used parenteral TU for >12 months. The mean duration of treatment was 90.6 weeks (54 to 150 weeks).
Body mass index (BMI), waist circumference, percentage body fat, total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, triglycerides, prostate-specific antigen (PSA), and hematocrit were measured. Further the Aging Male Symptoms' scale (AMS) and the International Index of Erectile Function (IIEF-5 and 15) were scored.
T therapy was associated with a significant decline in waist circumference (P=0.028) and percentage body fat (P<0.001), but no change of BMI. Total cholesterol and LDL cholesterol declined significantly (P=0.005 and P=0.024, respectively), with no significant changes of HDL cholesterol and triglycerides. The scores of sub-scales of AMS (psychological, somotovegetative and sexual factors) decreased (P=0.044, P=0.200 and P=0.071, respectively). The mean IIEF-5 (P=0.011) and IIEF-15 scores (P=0.021) improved significantly. Erectile function domain, orgasmic function domain, sexual desire domain, intercourse satisfaction domain, and overall satisfaction domain improved. Median PSA rose from 0.95 (0.640; 1.558) ng/mL to 1.480 (1.015; 2.275) ng/mL (P<0.001), with 11 patients >4ng/mL (4.01–13.21). On biopsy there was no evidence for malignancy. The mean hematocrit level increased significantly from 42.3±3.4% to 47.1±3.8%.
Normalizing serum T in men with LOH resulted in improvement of the metabolic syndrome, mood and sexual functions and appeared acceptably safe. Permpongkosol S, Tantirangsee N, and Ratana-olarn, K. Treatment of 161 men with symptomatic late onset hypogonadism with long-acting parenteral testosterone undecanoate: Effects on body composition, lipids, and psychosexual complaints.</abstract><cop>Malden, USA</cop><pub>Elsevier Inc</pub><pmid>20807330</pmid><doi>10.1111/j.1743-6109.2010.01994.x</doi><tpages>10</tpages></addata></record> |
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| subjects | Adult Age Factors Aged Aged, 80 and over Analysis of Variance Androgens - adverse effects Androgens - blood Androgens - therapeutic use Body Composition - drug effects Body Mass Index Health Status Indicators Humans Hypogonadism - drug therapy Hypogonadism - psychology Infusions, Parenteral International Index of Erectile Function Late-Onset Hypogonadism Lipids Male Middle Aged Prostate Safety Sex Hormone Binding Globulin Sexual Dysfunction, Physiological - drug therapy Sexual Dysfunction, Physiological - psychology Statistics, Nonparametric Surveys and Questionnaires Testosterone - adverse effects Testosterone - analogs & derivatives Testosterone - blood Testosterone - therapeutic use Testosterone Deficiency Syndrome Testosterone Undecanoate Thai Time Factors Waist Circumference |
| title | Treatment of 161 Men with Symptomatic Late Onset Hypogonadism with Long-Acting Parenteral Testosterone Undecanoate: Effects on Body Composition, Lipids, and Psychosexual Complaints |
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