Sensation evoked by esophageal distension in functional chest pain patients depends on mechanical stress rather than on ischemia

Background  Functional chest pain is commonly reproduced by bag distension in the esophageal body. It is unknown whether such pain is primarily associated with mechanical stress and strain (force‐deformation) or with changes in mucosal perfusion. Methods  Fourteen patients (6M, 8F, average age 55.9 ...

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Bibliographic Details
Published in:Neurogastroenterology and motility 2010-11, Vol.22 (11), p.1170-e311
Main Authors: Hoff, D. A. L., Gregersen, H., ødegaard, S., Hjertaker, B. T., Hatlebakk, J. G.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
biomechanics
Catheterization
Chest Pain - physiopathology
Data Interpretation, Statistical
Esophagus - blood supply
Esophagus - diagnostic imaging
Esophagus - physiology
Female
functional chest pain
Hemodynamics - physiology
Humans
ischemia
Ischemia - physiopathology
laser Doppler perfusion monitoring
Laser-Doppler Flowmetry
Male
Manometry
Middle Aged
Mucous Membrane - blood supply
Pain Measurement
Physical Stimulation
Regional Blood Flow - physiology
Stress, Mechanical
Ultrasonography
Young Adult
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Summary:Background  Functional chest pain is commonly reproduced by bag distension in the esophageal body. It is unknown whether such pain is primarily associated with mechanical stress and strain (force‐deformation) or with changes in mucosal perfusion. Methods  Fourteen patients (6M, 8F, average age 55.9 years) underwent ramp bag distension before and after injection of 20 mg butylscopolamine bromide (BS) using a novel bag catheter incorporating endosonography and laser Doppler perfusion monitoring. Healthy subjects served as controls. Mucosal perfusion was evaluated and stress and strain were computed and related to the sensation. Key Results  The symptom score increased with bag volume (P 
ISSN:1350-1925
1365-2982
DOI:10.1111/j.1365-2982.2010.01555.x