Interleukin-18 is a key mediator in dermatomyositis: potential contribution to development of interstitial lung disease

Objective. To determine whether IL-18 is involved in the inflammation of DM and PM. Methods. Thirty-three patients with DM were enrolled in this study, including 25 with interstitial lung disease (ILD). In addition, 16 patients with PM were enrolled, including 6 with ILD. All patients were admitted...

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Published in:Rheumatology (Oxford, England) England), 2010-10, Vol.49 (10), p.1878-1881
Main Authors: Gono, Takahisa, Kawaguchi, Yasushi, Sugiura, Tomoko, Ichida, Hisae, Takagi, Kae, Katsumata, Yasuhiro, Hanaoka, Masanori, Okamoto, Yuko, Ota, Yuko, Yamanaka, Hisashi
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Case-Control Studies
Dermatomyositis
Dermatomyositis - complications
Dermatomyositis - drug therapy
Diseases of the osteoarticular system
Ferritin
Ferritins - immunology
Humans
Interleukin-18
Interleukin-18 - immunology
Lung Diseases, Interstitial - drug therapy
Lung Diseases, Interstitial - etiology
Macrophage activation
Macrophages - immunology
Medical sciences
Middle Aged
Pneumology
Polymyositis
Polymyositis - complications
Polymyositis - drug therapy
Respiratory system : syndromes and miscellaneous diseases
Retrospective Studies
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Statistics as Topic
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Summary:Objective. To determine whether IL-18 is involved in the inflammation of DM and PM. Methods. Thirty-three patients with DM were enrolled in this study, including 25 with interstitial lung disease (ILD). In addition, 16 patients with PM were enrolled, including 6 with ILD. All patients were admitted to our hospital as a result of their condition requiring treatment, and clinical laboratory data including serum IL-18 were recorded on admission. Results. Serum IL-18 was significantly (P 
ISSN:1462-0324
1462-0332
DOI:10.1093/rheumatology/keq196