Haematopoietic cell transplantation as immunotherapy

The graft-versus-tumour effect seen after allogeneic (genetically different) haematopoietic cell transplantation for human malignancies represents the clearest example of the power of the human immune system to eradicate cancer. Recent advances in our understanding of the immunobiology of stem-cell...

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Bibliographic Details
Published in:Nature (London) 2001-05, Vol.411 (6835), p.385-389
Main Author: Appelbaum, F R
Format: Article
Language:English
Subjects:
Animals
Cancer
Care and treatment
Cells
Graft vs Host Disease - immunology
Graft vs Tumor Effect - immunology
Hematopoietic Stem Cell Transplantation
Humans
Immune system
Immune Tolerance - immunology
Immunotherapy
Methods
Neoplasms - immunology
Neoplasms - pathology
Neoplasms - therapy
stem cell transplantation
Stem cells
T-Lymphocytes - immunology
Transplantation
Transplants & implants
Tumors
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Description
Summary:The graft-versus-tumour effect seen after allogeneic (genetically different) haematopoietic cell transplantation for human malignancies represents the clearest example of the power of the human immune system to eradicate cancer. Recent advances in our understanding of the immunobiology of stem-cell engraftment, tolerance and tumour eradication are allowing clinicians to better harness this powerful effect.
ISSN:0028-0836
1476-4687
DOI:10.1038/35077251