Probing the Kinetics of Short‐Distance Drug Release from Nanocarriers to Nanoacceptors

Quick release: Polymer‐coated gold nanoparticles (AuNPs) are used as nanocarriers and nanoscale acceptors are used to represent proteins and lipid membranes in a model drug‐delivery system. The fluorescence of a drug is quenched in the vicinity of the AuNPs but reemerges upon its release (see pictur...

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Bibliographic Details
Published in:Angewandte Chemie (International ed.) 2010-11, Vol.49 (45), p.8426-8430
Main Authors: Wang, Hong, Xu, Jun, Wang, Jinghao, Chen, Tao, Wang, Yong, Tan, Yan Wen, Su, Haibin, Chan, Khai Leok, Chen, Hongyu
Format: Article
Language:English
Subjects:
diffusion model
Drug Carriers - chemistry
drug delivery
Gold - chemistry
Kinetics
Metal Nanoparticles - chemistry
Micelles
nanoparticles
Pharmaceutical Preparations - administration & dosage
Pharmaceutical Preparations - chemistry
Polymers - chemistry
Pyrenes - chemistry
Spectrometry, Fluorescence
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Summary:Quick release: Polymer‐coated gold nanoparticles (AuNPs) are used as nanocarriers and nanoscale acceptors are used to represent proteins and lipid membranes in a model drug‐delivery system. The fluorescence of a drug is quenched in the vicinity of the AuNPs but reemerges upon its release (see picture). The critical role of nanoacceptors in facilitating drug release is demonstrated.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201001065