Myxovirus replication in chicken embryos can be suppressed by aprotinin due to the blockage of viral glycoprotein cleavage

The D.I. Ivanovsky Institute of Virology, Moscow 123098, U.S.S.R. Injection of the protease inhibitor, aprotinin, into the allantoic cavity of embryonated eggs infected at low m.o.i. with different influenza viruses and paramyxoviruses markedly reduced multiplication by at least 100-fold. Under thes...

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Bibliographic Details
Published in:Journal of general virology 1985-07, Vol.66 (7), p.1633-1638
Main Authors: Zhirnov, O.P, Ovcharenko, A.V, Bukrinskaya, A.G
Format: Article
Language:English
Subjects:
Animals
Aprotinin - pharmacology
Biological and medical sciences
blockage
Chick Embryo
chickens
cleavage
embryo (animal)
Fundamental and applied biological sciences. Psychology
glycoproteins
Glycoproteins - metabolism
Influenza A virus - metabolism
Influenza A virus - physiology
Microbiology
Newcastle disease virus - metabolism
Newcastle disease virus - physiology
Parainfluenza Virus 1, Human - metabolism
Parainfluenza Virus 1, Human - physiology
Paramyxoviridae - physiology
Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains
Viral Proteins - metabolism
Virology
Virus Activation - drug effects
Virus Replication - drug effects
viruses
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Summary:The D.I. Ivanovsky Institute of Virology, Moscow 123098, U.S.S.R. Injection of the protease inhibitor, aprotinin, into the allantoic cavity of embryonated eggs infected at low m.o.i. with different influenza viruses and paramyxoviruses markedly reduced multiplication by at least 100-fold. Under these conditions, most viral particles produced were non-infectious and contained uncleaved glycoproteins, presumably resulting from aprotinin suppression of protease activity. Keywords: myxoviruses, aprotinin, glycoprotein cleavage Received 29 January 1985; accepted 15 March 1985.
ISSN:0022-1317
1465-2099
DOI:10.1099/0022-1317-66-7-1633