Fluconazole-Resistant Candida albicans

Mucocutaneous candidiasis caused by Candida albicans is a common complication of human immunodeficiency virus (HIV) infection. Recent reports of isolation of resistant strains of C. albicans raise the specter of more widespread resistance, but limited series are available to analyze situations in wh...

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Bibliographic Details
Published in:Clinical infectious diseases 1993-12, Vol.17 (6), p.1018-1021
Main Authors: Boken, Daniel J., Swindells, Susan, Rinaldi, Michael G.
Format: Article
Language:English
Subjects:
Adult
AIDS
AIDS-Related Opportunistic Infections - complications
AIDS-Related Opportunistic Infections - drug therapy
AIDS-Related Opportunistic Infections - microbiology
AIDS/HIV
Antifungal Agents - pharmacology
Antifungals
Biological and medical sciences
Candida albicans
Candida albicans - drug effects
Candidiasis
Candidiasis, Chronic Mucocutaneous - complications
Candidiasis, Chronic Mucocutaneous - drug therapy
Candidiasis, Chronic Mucocutaneous - microbiology
Clinical Infectious Disease Articles
Dosage
Drug interactions
Drug Resistance, Microbial
Fluconazole - therapeutic use
Fungal infections
HIV
Humans
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Infections
Male
Medical sciences
Microbial Sensitivity Tests
Oral candidiasis
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Summary:Mucocutaneous candidiasis caused by Candida albicans is a common complication of human immunodeficiency virus (HIV) infection. Recent reports of isolation of resistant strains of C. albicans raise the specter of more widespread resistance, but limited series are available to analyze situations in which the likelihood of resistance is greatest. We present our experience with fluconazole-resistant candidiasis in patients with HIV infection obtained from retrospective chart review and by testing strains of C. albicans isolated during relapse for susceptibility to antifungal agents. The possible reasons for failure of antifungal therapy are discussed, as well the correlation between in vivo and in vitro data. Resistant candidiasis in patients with HIV disease is an emerging problem of considerable concern that merits further study.
ISSN:1058-4838
1537-6591
DOI:10.1093/clinids/17.6.1018