Gastrointestinal injury in polycythemic term infants

Necrotizing enterocolitis is uncommon among term infants. In this group, necrotizing enterocolitis has been associated with two risk factors: polycythemia and umbilical catheterization. During a randomized trial of partial plasma exchange transfusion for treatment of polycythemia, an increased risk...

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Bibliographic Details
Published in:Pediatrics (Evanston) 1985-08, Vol.76 (2), p.225-231
Main Authors: BLACK, V. D, RUMACK, C. M, LUBCHENCO, L. O, KOOPS, B. L
Format: Article
Language:English
Subjects:
Biological and medical sciences
Blood Viscosity
Enterocolitis, Pseudomembranous - etiology
Gastroenterology. Liver. Pancreas. Abdomen
Hematocrit
Humans
Infant, Newborn
Medical sciences
Other diseases. Semiology
Plasma Exchange
Pneumatosis Cystoides Intestinalis - etiology
Polycythemia - complications
Polycythemia - therapy
Risk
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
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Summary:Necrotizing enterocolitis is uncommon among term infants. In this group, necrotizing enterocolitis has been associated with two risk factors: polycythemia and umbilical catheterization. During a randomized trial of partial plasma exchange transfusion for treatment of polycythemia, an increased risk of gastrointestinal problems was noted. Eight hyperviscous patients treated with partial plasma exchange transfusion, no symptomatically treated patients, and no control infants developed typical necrotizing enterocolitis (blood in the stools, pneumatosis, and systemic signs). The incidence of necrotizing enterocolitis was significantly greater among patients treated with exchange transfusion compared with patients treated symptomatically or control subjects (P less than .001).
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.76.2.225