Diastolic function in children and adolescents on dialysis and after kidney transplantation : an echocardiographic assessment

Thirty-seven children and adolescents on renal replacement therapy (11 on haemodialysis, 14 on continuous ambulatory peritoneal dialysis and 12 after renal transplantation) were studied by echocardiography, echo-Doppler and phonocardiography. Right and left ventricular (R/L V) diastolic functions we...

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Bibliographic Details
Published in:Pediatric nephrology (Berlin, West) West), 1993-12, Vol.7 (6), p.725-728
Main Authors: GOREN, A, GLASER, J, DRUKKER, A
Format: Article
Language:English
Subjects:
Adolescent
Adult
Anemia - complications
Anemia - physiopathology
Biological and medical sciences
Blood Pressure
Child
Child, Preschool
Diastole
Echocardiography
Electrocardiography
Female
Humans
Infant
Kidney Failure, Chronic - physiopathology
Kidney Failure, Chronic - surgery
Kidney Failure, Chronic - therapy
Kidney Transplantation - physiology
Male
Medical sciences
Nephrology. Urinary tract diseases
Nephropathies. Renovascular diseases. Renal failure
Peritoneal Dialysis, Continuous Ambulatory
Renal Dialysis
Renal failure
Ventricular Function
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Summary:Thirty-seven children and adolescents on renal replacement therapy (11 on haemodialysis, 14 on continuous ambulatory peritoneal dialysis and 12 after renal transplantation) were studied by echocardiography, echo-Doppler and phonocardiography. Right and left ventricular (R/L V) diastolic functions were measured by transmitral and transtricuspid flow velocities and by LV isovolumic relaxation time (LVIRT). Thirty-seven age- and sex-matched healthy subjects served as controls. R/L V diastolic dysfunction was only observed in the dialysis patients. In these patients LVIRT was prolonged. LV and RV peak inflow velocities were increased both in early (E) and late (A) diastole with a reduction in the E/A ratios. This pattern of diastolic dysfunction is compatible with the combined effects of a hypercirculatory state (volume overload, anaemia, arteriovenous fistula) and an abnormality of cardiac relaxation. The transplant patients showed no major cardiac abnormalities.
ISSN:0931-041X
1432-198X
DOI:10.1007/BF01213334