Bone changes from prostaglandin therapy

Prostaglandin E therapy in infants causes periosteal elevation. Although the changes usually take 30-40 days to become visible, we have seen them as early as nine days. In 15 infants who had prostaglandin E therapy for over six days, three developed periosteal elevation. Three other cases are descri...

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Bibliographic Details
Published in:Skeletal radiology 1985-01, Vol.14 (1), p.20-25
Main Authors: POZNANSKI, A. K, FERNBACH, S. K, BERRY, T. E
Format: Article
Language:English
Subjects:
Biological and medical sciences
Bone and Bones - diagnostic imaging
Drug toxicity and drugs side effects treatment
Ductus Arteriosus, Patent - drug therapy
Humans
Infant
Infant, Newborn
Male
Medical sciences
Miscellaneous (drug allergy, mutagens, teratogens...)
Periosteum - drug effects
Pharmacology. Drug treatments
Prostaglandins E - adverse effects
Prostaglandins E - therapeutic use
Radiography
Time Factors
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Description
Summary:Prostaglandin E therapy in infants causes periosteal elevation. Although the changes usually take 30-40 days to become visible, we have seen them as early as nine days. In 15 infants who had prostaglandin E therapy for over six days, three developed periosteal elevation. Three other cases are described in greater detail, with long-term follow-up in two in which the bone remodeled to normal. Gallium scan in one showed increased uptake in areas involved. The periosteal cloaking may mimic Caffey disease but the pattern of involvement is different, since the mandible, which is commonly affected in Caffey disease, is rarely involved in prostaglandin E therapy.
ISSN:0364-2348
1432-2161
DOI:10.1007/BF00361189