Arterial blood pressure in adult Nigerians with sickle cell anemia

• Published in: Journal of cardiology 2010-11, Vol.56 (3), p.326-331
• Main Authors: Oguanobi, N.I., MD, Onwubere, B.J.C., MD, Ibegbulam, O.G., MD, Ike, S.O., MD, Anisiuba, B.C., MD, Ejim, E.C., MD, Agwu, O., MD
• Format: Article
• Language: English
• Subjects: Adult; Anemia, Sickle Cell - physiopathology; Arterial blood pressure; Blood Pressure; Body Mass Index; Body Surface Area; Cardiovascular; Cross-Sectional Studies; Female; Hematocrit; Humans; Male; Nigeria; Sickle cell anemia; Steady state
• ISSN: 0914-5087; 1876-4738
• DOI: 10.1016/j.jjcc.2010.07.001

Summary Aim and objective This study was aimed at comparing the arterial blood pressures in steady state adult sickle cell patients with those of age- and sex-matched healthy controls. Methods A descriptive cross-sectional study of 62 sickle cell anemia patients and 62 age- and sex-matched healthy controls was carried out in the adult outpatient sickle cell clinics and the cardiac center of the University of Nigeria Teaching Hospital (UNTH), Enugu, Nigeria. Brachial blood pressures were measured in the right arm in all subjects. Results Significant increase in pulse rate was found in the study subjects (87.68 ± 8.91 bpm) compared with the controls (72.13 ± 6.79 bpm) ( p < 0.05). The mean systolic blood pressure was comparable in the two groups. However, the patients had significantly lower diastolic blood pressure, lower mean arterial blood pressure, as well as a higher pulse pressure than the control subjects. Significant correlations were found between blood pressure indices and hematocrit, body mass index, frequency of crisis, and body surface area. Conclusion Relatively lower arterial blood pressure is a significant finding in patients with sickle cell anemia. Hematocrit, frequency of crisis, body mass index, and body surface area are significant determinants of blood pressure indices in sickle cell anemia.