Atorvastatin Increases 25-Hydroxy Vitamin D Concentrations in Patients with Polycystic Ovary Syndrome

• Published in: Clinical chemistry (Baltimore, Md.) Md.), 2010-11, Vol.56 (11), p.1696-1700
• Main Authors: SATHYAPALAN, Thozhukat, SHEPHERD, John, ARNETT, Charlotte, COADY, Anne-Marie, KILPATRICK, Eric S, ATKIN, Stephen L
• Format: Article
• Language: English
• Subjects: Adult; Analytical, structural and metabolic biochemistry; Arthritis; Atorvastatin; Autoimmune diseases; Biological and medical sciences; Cardiovascular disease; Chromatography; Double-Blind Method; Drug therapy; Female; Fundamental and applied biological sciences. Psychology; Heptanoic Acids - therapeutic use; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use; Independent sample; Insulin resistance; Investigative techniques, diagnostic techniques (general aspects); Mass spectrometry; Medical sciences; Molecular biophysics; Mortality; Polycystic ovary syndrome; Polycystic Ovary Syndrome - blood; Polycystic Ovary Syndrome - drug therapy; Pyrroles - therapeutic use; Rheumatoid arthritis; Statins; Statistical analysis; Studies; Vitamin D; Vitamin D - analogs & derivatives; Vitamin D - blood; Womens health
• ISSN: 0009-9147; 1530-8561
• DOI: 10.1373/clinchem.2010.144014

It has been shown that many women with polycystic ovary syndrome (PCOS) are 25-hydroxyvitamin D (25OHD) insufficient. Both statin treatment and vitamin D supplementation have been shown to improve biochemical hyperandrogenemia, insulin resistance, and markers of inflammation in patients with PCOS, raising the possibility that some of the statin effects are mediated through vitamin D. We conducted this randomized, double-blind placebo controlled study to assess the effect of atorvastatin on serum 25OHD concentrations in patients with PCOS. Forty medication-naive patients with PCOS were randomized to either atorvastatin 20 mg daily or placebo for 3 months. After completing the initial 3 months of atorvastatin or placebo, both groups of patients participated in a 3-month extension study with metformin 1500 mg daily. We measured changes in 25OHD concentrations by use of tandem mass spectrometry. Mean (SD) baseline 25OHD concentrations were comparable between the 2 groups [45.9 (2.4) vs 44.8 (1.8) nmol/L; P = 0.7]. There was a significant increase in 25OHD concentrations with atorvastatin [45.9 (2.4) vs 60.8 (3.5) nmol/L] compared with placebo [44.8 (1.8) vs 41.8 (3.2) nmol/L; P = 0.02]. Three-month treatment with metformin maintained the improvement of 25OHD with atorvastatin compared to baseline [45.9 (2.4) vs 61.8 (3.5), P ≤ 0.01). There were no significant changes in 25OHD concentrations in the placebo group after 12 weeks of metformin. Among patients with polycystic ovary syndrome, 12 weeks of atorvastatin led to a clinically significant rise in 25OHD concentrations. This may represent a beneficial pleiotropic effect of statins on 25OHD concentrations.