Seroprevalence of varicella‐zoster virus in Korea

Varicella‐zoster virus (VZV) causes chickenpox and herpes zoster. Korea is assumed to have a high seroprevalence of VZV, although data are scant. A cross‐sectional and age‐stratified study was conducted to investigate the seroprevalence of VZV in different ages in the South Korean population. Four m...

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Bibliographic Details
Published in:Journal of medical virology 2010-12, Vol.82 (12), p.2123-2126
Main Authors: Choi, Won Suk, Noh, Ji Yun, Huh, Joong Yeon, Jo, Yu Mi, Lee, Jacob, Song, Joon Young, Kim, Woo Joo, Cheong, Hee Jin
Format: Article
Language:English
Subjects:
Adolescent
Age Distribution
Antibodies, Viral - blood
Biological and medical sciences
Child
Child, Preschool
Epidemiology
Female
Fundamental and applied biological sciences. Psychology
herpes zoster
Herpes Zoster - epidemiology
Herpes Zoster - virology
Herpesvirus 3, Human - immunology
Human viral diseases
Humans
Immunoglobulin G - blood
Infant
Infectious diseases
Male
Medical sciences
Microbiology
Miscellaneous
Republic of Korea - epidemiology
Seroepidemiologic Studies
seroprevalence
varicella
varicella zoster virus
Viral diseases
Virology
Young Adult
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Summary:Varicella‐zoster virus (VZV) causes chickenpox and herpes zoster. Korea is assumed to have a high seroprevalence of VZV, although data are scant. A cross‐sectional and age‐stratified study was conducted to investigate the seroprevalence of VZV in different ages in the South Korean population. Four medical institutions were chosen in the southwestern area of Seoul in the vicinity of Gyeonggi‐do. Serum samples were obtained at each institution from consenting patients during April-August, 2008. Anti‐VZV IgG antibody was measured by an enzyme immunoassay. Of the 887 patients, 87.6% had anti‐VZV IgG antibody. The prevalence of anti‐VZV IgG antibody was 75% during the first 3 months after birth, but was only 13.6% 12 months after birth. Anti‐VZV IgG antibody prevalence increased, first at 1-2 years of age, and then at 5-6 years of age. The seroprevalence rate exceeded 90% in subjects over 11 years of age. The results show that the seroprevalence of VZV is relatively high in the South Korean population. A study on the rate of varicella vaccination and the vaccine's efficacy in South Korea is warranted. J. Med. Virol. 82:2123-2126, 2010.
ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.21917