Association of XIAP and P2X7 receptor expression with lymph node metastasis in papillary thyroid carcinoma

• Published in: Endocrine 2010-10, Vol.38 (2), p.276-282
• Main Authors: Gu, Li-Qun, Li, Feng-Ying, Zhao, Lin, Liu, Yun, Chu, Qian, Zang, Xun-Xiong, Liu, Jian-Min, Ning, Guang, Zhao, Yong-Ju
• Format: Article
• Language: English
• Subjects: Adult; Biomarkers, Tumor - metabolism; Carcinoma, Papillary - metabolism; Carcinoma, Papillary - secondary; Diabetes; Endocrinology; Female; Goiter, Nodular - metabolism; Goiter, Nodular - pathology; Humanities and Social Sciences; Humans; Internal Medicine; Lymphatic Metastasis - pathology; Male; Medicine; Medicine & Public Health; Middle Aged; multidisciplinary; Original Article; Predictive Value of Tests; Prognosis; Receptors, Purinergic P2X7 - metabolism; Science; Thyroid Neoplasms - metabolism; Thyroid Neoplasms - pathology; X-Linked Inhibitor of Apoptosis Protein - metabolism
• ISSN: 1355-008X; 1559-0100
• DOI: 10.1007/s12020-010-9384-7

The expression of X-linked inhibitor of apoptosis (XIAP) and the P2X 7 receptor were demonstrated in a variety of tumors. The purpose of the present study was to investigate the associations of XIAP and P2X 7 receptor expression with the clinicopathological features of patients with papillary thyroid carcinoma (PTC). In this cross-sectional study, a total of 62 cases were examined, including 43 patients with PTCs and 19 with benign nodular goiters. XIAP and P2X 7 receptor expression were examined by immunohistochemical methods on formalin-fixed, paraffin-embedded thyroid tissues. The staining intensity and extent were evaluated and scored using a semi-quantitative method. The immunohistochemical staining score integrating the intensity and extent of XIAP and P2X 7 receptors in PTCs was higher than in nodular goiters. XIAP (OR: 5.6, 95% CI: 1.5–21.1, P  = 0.009) and P2X 7 receptor (OR: 6.1, 95% CI: 1.5–24.4, P  = 0.007) expression were associated with lymph node metastasis in PTCs. In logistic regression analysis, P2X 7 receptor expression, tumor size, and capsular infiltration were predictors for lymph node metastasis ( P  = 0.001). Our results suggested that XIAP and P2X 7 receptor expression may predict the aggressiveness of PTC.