Distribution of Fatty Acids Reveals the Functional Structure of Human Serum Albumin

Flexible on the outside: The functional structure of the transport protein in human blood, human serum albumin (HSA), was characterized by distance measurements with double electron–electron resonance (DEER) spectroscopy on spin‐labeled fatty acids that are bound to HSA. The functional protein struc...

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Bibliographic Details
Published in:Angewandte Chemie (International ed.) 2010-11, Vol.49 (46), p.8755-8759
Main Authors: Junk, Matthias J.N, Spiess, Hans Wolfgang, Hinderberger, Dariush
Format: Article
Language:English
Subjects:
albumin
Electron Spin Resonance Spectroscopy
EPR spectroscopy
fatty acids
Fatty Acids - chemistry
Humans
nanostructures
Nanostructures - chemistry
Protein Binding
Protein Structure, Tertiary
protein structures
Serum Albumin - chemistry
Spin Labels
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Summary:Flexible on the outside: The functional structure of the transport protein in human blood, human serum albumin (HSA), was characterized by distance measurements with double electron–electron resonance (DEER) spectroscopy on spin‐labeled fatty acids that are bound to HSA. The functional protein structure derived has a more rigid inner core, while the surface of the protein shows much greater structural flexibility.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201003495