PHARMACOKINETICS OF PHENOPERIDINE IN ANAESTHETIZED PATIENTS UNDERGOING GENERAL SURGERY

The pharmacokinetics of phenoperidine have been studied in five anaesthetized patients receiving a 2-mg bolus dose i.v. Plasma concentrations were measured using a sensitive radioimmunoassay method. The distribution of phenoperidine was described according to a two-compartment open model. The mean d...

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Bibliographic Details
Published in:British journal of anaesthesia : BJA 1985-09, Vol.57 (9), p.872-876
Main Authors: FISCHLER, M., LEVRON, J.C., TRANG, H., VAXELAIRE, J.F., FLAISLER, B., VOURC’H, G.
Format: Article
Language:English
Subjects:
Anesthesia, General
Anesthetics. Neuromuscular blocking agents
Biological and medical sciences
Female
Half-Life
Humans
Intraoperative Period
Kinetics
Male
Medical sciences
Middle Aged
Models, Biological
Neuropharmacology
Pharmacology. Drug treatments
Phenoperidine - blood
Radioimmunoassay
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Summary:The pharmacokinetics of phenoperidine have been studied in five anaesthetized patients receiving a 2-mg bolus dose i.v. Plasma concentrations were measured using a sensitive radioimmunoassay method. The distribution of phenoperidine was described according to a two-compartment open model. The mean distribution half-life (T½α) for the five patients was short (2.2 min); the mean elimination half-life (T½β) was 193 min. The mean whole body clearance was 22 ml min-1 kg-1 and the apparent steady state distribution volume (VSS) was 5.7 litre kg-1. Secondary concentration peaks occurred in all patients; in two patients these were substantial and occurred 80 min after injection.
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/57.9.872