Amino Acid Sequence of Glutathione S-Transferase a from Guinea Pig Liver

The amino acid sequence of glutathione S-transferase a from guinea pig liver was determined. Glutathione S-transferase a was composed of two identical subunits, each comprising 218 amino acid residues. The amino acid sequence of glutathione S-transferase a; exhibited 73% homology with that of human...

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Bibliographic Details
Published in:Journal of biochemistry (Tokyo) 1993-12, Vol.114 (6), p.835-841
Main Authors: Kamei-Hayashi, Raeko, Oshino, Reiko, Hara, Saburo
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Cyanogen Bromide
Glutathione Transferase - classification
Glutathione Transferase - isolation & purification
Guinea Pigs
Humans
Liver - enzymology
Molecular Sequence Data
Molecular Weight
Peptide Fragments - isolation & purification
Rats
Sequence Homology, Amino Acid
Trypsin
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Summary:The amino acid sequence of glutathione S-transferase a from guinea pig liver was determined. Glutathione S-transferase a was composed of two identical subunits, each comprising 218 amino acid residues. The amino acid sequence of glutathione S-transferase a; exhibited 73% homology with that of human glutathione S-transferase Ha, 69% with that of rat glutathione S-transferase Ya, and 68% with that of rat glutathione S-transferase Yc, which are known to belong to class Alpha. From the above result, together with previous observations on its substrate specificity, it was concluded that glutathione S-transferase a belonged to class Alpha.
ISSN:0021-924X
1756-2651
DOI:10.1093/oxfordjournals.jbchem.a124265