Postoperative pain relief with naloxone, Severe respiratory depression and pain after high dose buprenorphine

Summary Buprenorphine 30 and 40 μg/kg was given as the sole intravenous analgesic in balanced anaesthesia to 12 patients undergoing cholecystectomy. Significant and severe respiratory depression was found 15 minutes after pre‐operative loading with buprenorphine. In the immediate postoperative perio...

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Bibliographic Details
Published in:Anaesthesia 1985-06, Vol.40 (6), p.583-586
Main Authors: Schmidt, J.F., Chræmmer‐Jørgensen, B., Pedersen, J.E., Risbo, A.
Format: Article
Language:English
Subjects:
Adult
Analgesia
postoperative
Analgesic, narcotic
buprenorphine
Analgesics
Anesthesia, Intravenous
Biological and medical sciences
Buprenorphine - therapeutic use
Depression, Chemical
Humans
Medical sciences
Middle Aged
Morphinans - therapeutic use
Naloxone - therapeutic use
Neuropharmacology
Pain, Postoperative - drug therapy
Pharmacology. Drug treatments
Prospective Studies
Respiration - drug effects
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Summary:Summary Buprenorphine 30 and 40 μg/kg was given as the sole intravenous analgesic in balanced anaesthesia to 12 patients undergoing cholecystectomy. Significant and severe respiratory depression was found 15 minutes after pre‐operative loading with buprenorphine. In the immediate postoperative period six patients were in pain. They were treated with naloxone 0.08–0.4 mg leading to a long lasting period of pain relief (median 22 hours).
ISSN:0003-2409
1365-2044
DOI:10.1111/j.1365-2044.1985.tb10903.x