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Malignancy in Systemic Lupus Erythematosus: a Report of Five Cases in a Series of 96 Patients
The association of systemic lupus erythematosus (SLE) and malignancy has been reported previously and suggests an increased risk of cancer in this disease. Lymphomas are the most frequent neoplasias reported in these patients and carcinoma of the cervix and breast are also seen. Several factors prob...
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Published in: | Lupus 1993-12, Vol.2 (6), p.377-380 |
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creator | Lopez Dupla, Miguel Khamashta, Munther Garcia, Vicente Pintado Uriol, Paz Lavilla Ortega, Eulalia Valencia Gil Aguado, Antonio |
description | The association of systemic lupus erythematosus (SLE) and malignancy has been reported previously and suggests an increased risk of cancer in this disease. Lymphomas are the most frequent neoplasias reported in these patients and carcinoma of the cervix and breast are also seen. Several factors probably play a role in the aetiology of malignancies associated with SLE including intrinsic disturbances of immunity and concomitant immunosuppressive therapy. We report five solid tumors (one breast carcinoma, one squamous cell carcinoma of the anus, one adenocarcinoma of the rectum, one carcinoma of the cervix and one carcinoma of the gallbladder) among 96 patients with SLE. The most striking finding in this study was the absence of haematological malignancies. The incidence of malignancy in the series, the age of diagnosis of SLE and neoplasia and the time delay between SLE and malignancy diagnosis was similar to other series. We did not find any clinical or immunological feature that predicted the development of neoplasia.
In conclusion, patients with SLE may have the same malignancies as the general population after adjustment for age and sex. There are no predictive indicators for malignancy and immunosuppressive therapy may be a contributing factor. |
doi_str_mv | 10.1177/096120339300200608 |
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In conclusion, patients with SLE may have the same malignancies as the general population after adjustment for age and sex. There are no predictive indicators for malignancy and immunosuppressive therapy may be a contributing factor.</description><identifier>ISSN: 0961-2033</identifier><identifier>EISSN: 1477-0962</identifier><identifier>DOI: 10.1177/096120339300200608</identifier><identifier>PMID: 8136821</identifier><language>eng</language><publisher>Thousand Oaks, CA: SAGE Publications</publisher><subject>Adenocarcinoma - complications ; Adolescent ; Adult ; Aged ; Anus Neoplasms - complications ; Breast Neoplasms - complications ; Carcinoma, Ductal, Breast - complications ; Carcinoma, Squamous Cell - complications ; Child ; Child, Preschool ; Female ; Gallbladder Neoplasms - complications ; Humans ; Immunosuppressive Agents - adverse effects ; Infant ; Lupus Erythematosus, Systemic - complications ; Lupus Erythematosus, Systemic - drug therapy ; Male ; Middle Aged ; Neoplasms - complications ; Neoplasms - etiology ; Rectal Neoplasms - complications ; Time Factors ; Uterine Cervical Neoplasms - complications</subject><ispartof>Lupus, 1993-12, Vol.2 (6), p.377-380</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c380t-d0fe154d4711fdc502fc2d7afe68dc1dc97f0e48008eb8c68927720ca0d1c663</citedby><cites>FETCH-LOGICAL-c380t-d0fe154d4711fdc502fc2d7afe68dc1dc97f0e48008eb8c68927720ca0d1c663</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/096120339300200608$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/096120339300200608$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21845,27924,27925,45082,45470</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8136821$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lopez Dupla, Miguel</creatorcontrib><creatorcontrib>Khamashta, Munther</creatorcontrib><creatorcontrib>Garcia, Vicente Pintado</creatorcontrib><creatorcontrib>Uriol, Paz Lavilla</creatorcontrib><creatorcontrib>Ortega, Eulalia Valencia</creatorcontrib><creatorcontrib>Gil Aguado, Antonio</creatorcontrib><title>Malignancy in Systemic Lupus Erythematosus: a Report of Five Cases in a Series of 96 Patients</title><title>Lupus</title><addtitle>Lupus</addtitle><description>The association of systemic lupus erythematosus (SLE) and malignancy has been reported previously and suggests an increased risk of cancer in this disease. Lymphomas are the most frequent neoplasias reported in these patients and carcinoma of the cervix and breast are also seen. Several factors probably play a role in the aetiology of malignancies associated with SLE including intrinsic disturbances of immunity and concomitant immunosuppressive therapy. We report five solid tumors (one breast carcinoma, one squamous cell carcinoma of the anus, one adenocarcinoma of the rectum, one carcinoma of the cervix and one carcinoma of the gallbladder) among 96 patients with SLE. The most striking finding in this study was the absence of haematological malignancies. The incidence of malignancy in the series, the age of diagnosis of SLE and neoplasia and the time delay between SLE and malignancy diagnosis was similar to other series. We did not find any clinical or immunological feature that predicted the development of neoplasia.
In conclusion, patients with SLE may have the same malignancies as the general population after adjustment for age and sex. There are no predictive indicators for malignancy and immunosuppressive therapy may be a contributing factor.</description><subject>Adenocarcinoma - complications</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Anus Neoplasms - complications</subject><subject>Breast Neoplasms - complications</subject><subject>Carcinoma, Ductal, Breast - complications</subject><subject>Carcinoma, Squamous Cell - complications</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>Gallbladder Neoplasms - complications</subject><subject>Humans</subject><subject>Immunosuppressive Agents - adverse effects</subject><subject>Infant</subject><subject>Lupus Erythematosus, Systemic - complications</subject><subject>Lupus Erythematosus, Systemic - drug therapy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasms - complications</subject><subject>Neoplasms - etiology</subject><subject>Rectal Neoplasms - complications</subject><subject>Time Factors</subject><subject>Uterine Cervical Neoplasms - complications</subject><issn>0961-2033</issn><issn>1477-0962</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><recordid>eNp9kEFLw0AQhRdRaq3-AUHYk55iZzbp7sablFaFimJ7lbDdTGpKk9TdROi_N6HFi9DTDLzvvcPH2DXCPaJSQ4glCgjDOAQQABL0CetjpFTQJuKU9Tsg6IhzduH9GgBCjGWP9TSGUgvss89Xs8lXpSntjucln-98TUVu-azZNp5P3K7-osLUlW_8Azf8g7aVq3mV8Wn-Q3xsPPmuZ_icXN7-bRJL_m7qnMraX7KzzGw8XR3ugC2mk8X4OZi9Pb2MH2eBDTXUQQoZ4ShKI4WYpXYEIrMiVSYjqVOLqY1VBhRpAE1LbaWOhVICrIEUrZThgN3uZ7eu-m7I10mRe0ubjSmpanyipJBRONIteHccjCKJiBC3pNiT1lXeO8qSrcsL43YJQtLJT_7Lb0s3h_lmWVD6VznYbvPhPvdmRcm6alzZWjm2-AsaMosd</recordid><startdate>199312</startdate><enddate>199312</enddate><creator>Lopez Dupla, Miguel</creator><creator>Khamashta, Munther</creator><creator>Garcia, Vicente Pintado</creator><creator>Uriol, Paz Lavilla</creator><creator>Ortega, Eulalia Valencia</creator><creator>Gil Aguado, Antonio</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>199312</creationdate><title>Malignancy in Systemic Lupus Erythematosus: a Report of Five Cases in a Series of 96 Patients</title><author>Lopez Dupla, Miguel ; Khamashta, Munther ; Garcia, Vicente Pintado ; Uriol, Paz Lavilla ; Ortega, Eulalia Valencia ; Gil Aguado, Antonio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c380t-d0fe154d4711fdc502fc2d7afe68dc1dc97f0e48008eb8c68927720ca0d1c663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adenocarcinoma - complications</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Anus Neoplasms - complications</topic><topic>Breast Neoplasms - complications</topic><topic>Carcinoma, Ductal, Breast - complications</topic><topic>Carcinoma, Squamous Cell - complications</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>Gallbladder Neoplasms - complications</topic><topic>Humans</topic><topic>Immunosuppressive Agents - adverse effects</topic><topic>Infant</topic><topic>Lupus Erythematosus, Systemic - complications</topic><topic>Lupus Erythematosus, Systemic - drug therapy</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasms - complications</topic><topic>Neoplasms - etiology</topic><topic>Rectal Neoplasms - complications</topic><topic>Time Factors</topic><topic>Uterine Cervical Neoplasms - complications</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lopez Dupla, Miguel</creatorcontrib><creatorcontrib>Khamashta, Munther</creatorcontrib><creatorcontrib>Garcia, Vicente Pintado</creatorcontrib><creatorcontrib>Uriol, Paz Lavilla</creatorcontrib><creatorcontrib>Ortega, Eulalia Valencia</creatorcontrib><creatorcontrib>Gil Aguado, Antonio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Lupus</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lopez Dupla, Miguel</au><au>Khamashta, Munther</au><au>Garcia, Vicente Pintado</au><au>Uriol, Paz Lavilla</au><au>Ortega, Eulalia Valencia</au><au>Gil Aguado, Antonio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Malignancy in Systemic Lupus Erythematosus: a Report of Five Cases in a Series of 96 Patients</atitle><jtitle>Lupus</jtitle><addtitle>Lupus</addtitle><date>1993-12</date><risdate>1993</risdate><volume>2</volume><issue>6</issue><spage>377</spage><epage>380</epage><pages>377-380</pages><issn>0961-2033</issn><eissn>1477-0962</eissn><abstract>The association of systemic lupus erythematosus (SLE) and malignancy has been reported previously and suggests an increased risk of cancer in this disease. Lymphomas are the most frequent neoplasias reported in these patients and carcinoma of the cervix and breast are also seen. Several factors probably play a role in the aetiology of malignancies associated with SLE including intrinsic disturbances of immunity and concomitant immunosuppressive therapy. We report five solid tumors (one breast carcinoma, one squamous cell carcinoma of the anus, one adenocarcinoma of the rectum, one carcinoma of the cervix and one carcinoma of the gallbladder) among 96 patients with SLE. The most striking finding in this study was the absence of haematological malignancies. The incidence of malignancy in the series, the age of diagnosis of SLE and neoplasia and the time delay between SLE and malignancy diagnosis was similar to other series. We did not find any clinical or immunological feature that predicted the development of neoplasia.
In conclusion, patients with SLE may have the same malignancies as the general population after adjustment for age and sex. There are no predictive indicators for malignancy and immunosuppressive therapy may be a contributing factor.</abstract><cop>Thousand Oaks, CA</cop><pub>SAGE Publications</pub><pmid>8136821</pmid><doi>10.1177/096120339300200608</doi><tpages>4</tpages></addata></record> |
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subjects | Adenocarcinoma - complications Adolescent Adult Aged Anus Neoplasms - complications Breast Neoplasms - complications Carcinoma, Ductal, Breast - complications Carcinoma, Squamous Cell - complications Child Child, Preschool Female Gallbladder Neoplasms - complications Humans Immunosuppressive Agents - adverse effects Infant Lupus Erythematosus, Systemic - complications Lupus Erythematosus, Systemic - drug therapy Male Middle Aged Neoplasms - complications Neoplasms - etiology Rectal Neoplasms - complications Time Factors Uterine Cervical Neoplasms - complications |
title | Malignancy in Systemic Lupus Erythematosus: a Report of Five Cases in a Series of 96 Patients |
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