Immune reactivity to Thomsen-Friedenreich antigen in patients with lung cancer detected by superoxide assay-leukocyte adherence inhibition test

The immune reactivity to partially purified Thomsen-Friedenreich antigen was investigated in patients with lung cancer. The modified method of original leukocyte adherence inhibition test, termed superoxide assay-leukocyte adherence inhibition test, was used to detect the reactivity. The coded perip...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 1985-09, Vol.45 (9), p.4473-4477
Main Authors: ICHINOSE, Y, YAGAWA, K, KAKU, M, HARA, N, OHTA, M
Format: Article
Language:English
Subjects:
Adult
Aged
Antigens, Neoplasm - immunology
Antigens, Tumor-Associated, Carbohydrate
Biological and medical sciences
Disaccharides - immunology
Female
Humans
Leukocyte Adherence Inhibition Test
Lung Neoplasms - immunology
Lymphocytes - immunology
Male
Medical sciences
Middle Aged
Monocytes - immunology
Pneumology
Superoxides - metabolism
Tumors of the respiratory system and mediastinum
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Summary:The immune reactivity to partially purified Thomsen-Friedenreich antigen was investigated in patients with lung cancer. The modified method of original leukocyte adherence inhibition test, termed superoxide assay-leukocyte adherence inhibition test, was used to detect the reactivity. The coded peripheral mononuclear cells from 34 of 50 (68%) patients with lung cancer showed a positive response to the antigen whereas in only 3 of 19 (16%) patients with benign pulmonary disease was there a reaction to the antigen. The same experiments were performed using the 3 m KCl extract of lung tumors as an antigen. In this case in 39 of 50 (78%) patients with lung cancer but in only 4 of 24 (17%) with benign pulmonary disease and in none of the breast cancer patients (0 of 17) was there a reaction to the antigen. These results strongly suggest that patients with lung cancer are sensitized to both Thomsen-Friedenreich antigen and tumor-associated antigens expressed in cancer cells of lung tissue origin.
ISSN:0008-5472
1538-7445