Hepatoblastoma producing both alpha‐fetoprotein and human chorionic gonadotropin clinicopathologic analysis of four cases and a review of the literature

A clinicopathologic study was done of four cases of hepatoblastoma with precocious puberty, together with an analysis of 21 such cases reported in the literature. All four patients were males, the age ranging from 11 to 35 months. Three of the four patients died within 12 months after operation, but...

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Bibliographic Details
Published in:Cancer 1985-10, Vol.56 (7), p.1636-1642
Main Authors: Nakagawara, Akira, Ikeda, Keiichi, Tsuneyoshi, Masazumi, Daimaru, Yutaka, Enjoji, Munetomo, Watanabe, Itaru, Iwafuchi, Makoto, Sawada, Tadashi
Format: Article
Language:English
Subjects:
alpha-Fetoproteins - analysis
Biological and medical sciences
Carcinoma, Hepatocellular - analysis
Carcinoma, Hepatocellular - pathology
Child, Preschool
Chorionic Gonadotropin - analysis
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Immunoenzyme Techniques
Infant
Liver Neoplasms - analysis
Liver Neoplasms - pathology
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Male
Medical sciences
Prognosis
Tumors
Citations: Items that this one cites
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Summary:A clinicopathologic study was done of four cases of hepatoblastoma with precocious puberty, together with an analysis of 21 such cases reported in the literature. All four patients were males, the age ranging from 11 to 35 months. Three of the four patients died within 12 months after operation, but the fourth is living. Histologically, all patients had a hepatoblastoma with the coexistence of both fetal and embryonal type cells, although predominantly fetal in two and predominantly embryonal in the other two. Tumor giant cells were rarely encountered in all these cases. Both alpha‐fetoprotein (AFP) and human chorionic gonadotropin (hCG) in the serum or urine increased in our four cases and in five other cases reported in the literature. Though the serum AFP level paralleled the severity of clinical symptoms, the serum or urine hCG did not necessarily correspond to the clinical course. It is likely that these poorly prognostic virilizing hepatoblastomas secrete two different tumor markers, AFP and hCG, from different cells, and that these functioning tumor cells may not always exist concurrently in the recurrent or metastatic tumor. Cancer 56: 1636‐1642, 1985.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19851001)56:7<1636::AID-CNCR2820560729>3.0.CO;2-R