Stimulation of guanylate cyclase by atrial natriuretic factor in isolated human glomeruli

A 23 amino acid synthetic peptide fragment of atrial natriuretic factor (ANF) stimulated guanylate cyclase activity in isolated human glomeruli in a concentration- and time-dependent manner. ANF activated particulate guanylate cyclase whereas it had no effect on soluble guanylate cyclase. These resu...

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Bibliographic Details
Published in:FEBS letters 1985-09, Vol.189 (1), p.8-12
Main Authors: Ardaillou, Nicole, Nivez, Marie-Paule, Ardaillou, Raymond
Format: Article
Language:English
Subjects:
Analytical, structural and metabolic biochemistry
Atrial Natriuretic Factor
Biological and medical sciences
Cyclic GMP - metabolism
Enzyme Activation
Enzymes and enzyme inhibitors
Fundamental and applied biological sciences. Psychology
Guanylate Cyclase - metabolism
Humans
Kidney Glomerulus - drug effects
Kidney Glomerulus - enzymology
Lyases
Natriuretic Agents
Peptide Fragments - analysis
Proteins - pharmacology
Time Factors
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Summary:A 23 amino acid synthetic peptide fragment of atrial natriuretic factor (ANF) stimulated guanylate cyclase activity in isolated human glomeruli in a concentration- and time-dependent manner. ANF activated particulate guanylate cyclase whereas it had no effect on soluble guanylate cyclase. These results demonstrate that the glomerulus is a target structure for ANF in humans. They also suggest that ANF-induced increase in glomerular filtration rate is due to a direct effect of this peptide on the glomerular cells mediated by activation of glomerular guanylate cyclase. Atrial natriuretic factor Isolated glomerulus Guanylate cyclase Cyclic GMP
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(85)80831-0