Interspecies pharmacokinetic scaling of Sch 34343

Pharmacokinetic parameters of Sch 34343 have been determined for mice, rats, rabbits, monkeys, dogs and humans and correlated among species as an exponential function of body weight. The pertinent pharmacokinetic parameters tested are apparent and steady-state volumes of distribution, total body cle...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 1985-01, Vol.15 (suppl-C), p.227-233
Main Authors: Chung, Menger, Radwanski, Elaine, Loebenberg, David, Lin, Chin-Chung, Oden, Edwin, Symchowicz, Samson, Gural, Richard P., Miller, G. H.
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - blood
Anti-Bacterial Agents - metabolism
Body Weight
Dogs
Humans
Injections, Intravenous
Kinetics
Lactams
Macaca fascicularis
Male
Mice
Rabbits
Rats
Saimiri
Species Specificity
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Summary:Pharmacokinetic parameters of Sch 34343 have been determined for mice, rats, rabbits, monkeys, dogs and humans and correlated among species as an exponential function of body weight. The pertinent pharmacokinetic parameters tested are apparent and steady-state volumes of distribution, total body clearance, elimination phase half-life, and mean residence time. This study showed that the extrapolation of animal data to humans on a new investigational drug, Sch 34343, can be potentially useful.
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/15.suppl_C.227