Exercise Training Attenuates Stress-Induced Hypertension in the Rat

The ability of exercise training to block the generation of hypertension produced by chronic stress in the borderline hypertensive rat was tested. Twenty-three male borderline hypertensive rats, Fi offspring of spontaneously hypertensive and Wistar-Kyoto rats, were divided into three groups. Two gro...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 1985-09, Vol.7 (5), p.747-751
Main Authors: COX, RONALD H, HUBBARD, JOHN W, LAWLER, JAMES E, SANDERS, BRIAN J, MITCHELL, VICKI P
Format: Article
Language:English
Subjects:
Analysis of Variance
Animals
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Blood Pressure
Bradycardia - physiopathology
Cardiology. Vascular system
Epinephrine - blood
Experimental diseases
Hypertension - etiology
Male
Medical sciences
Norepinephrine - blood
Physical Exertion
Rats
Rest
Stress, Physiological - complications
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Summary:The ability of exercise training to block the generation of hypertension produced by chronic stress in the borderline hypertensive rat was tested. Twenty-three male borderline hypertensive rats, Fi offspring of spontaneously hypertensive and Wistar-Kyoto rats, were divided into three groups. Two groups (8 rats per group) were subjected to 2 hours of daily, predictable, uncontrollable tail shock for 12 weeks. One of these groups was also given 2 hours of daily swim stress (exercise trained). A third group served as a maturation control and received neither intervention (n = 7). After 12 weeks of stress, direct recording of blood pressure verified the pattern observed with tail cuffshock only group, 180/118 ± 3β mm Hg; exercise-trained and shocked group, 1667108 ± 4/2 mm Hg; and control group, 160/98 ± 6/4 mm Hg (mean ± SEM). Systolic and diastolic blood pressures in the shock only group were significantly higher than in both the other groups (p < 0.05). The control group differed from the exercise-trained and shocked group only in diastolic BP (p < 0.05). During a shortterm stress session plasma norepinephrine levels in the exercise-trained and shocked group were significantly lower than those in the shock only group (555 ± 56 vs 776 ± 84 pg/ml; p < 0.05). These results indicate that an alteration of autonomic function resulted from the exercise training, but its contribution to the resistance of the exercise-trained and shocked rats to stress-induced hypertension is unclear.
ISSN:0194-911X
1524-4563
DOI:10.1161/01.HYP.7.5.747