beta-Lactamase susceptibility and comparative activity of Sch 34343 and other beta-lactams for non-fermenters, Neisseria spp. and beta-lactamase-positive Enterobacteriaceae

By means of a micro-dilution technique (10(5) cfu/cup) 30 strains of Pseudomonas spp. were found resistant to Sch 34343. The susceptibility of Acinetobacter spp. (20 strains) was greatest for imipenem, followed by Sch 34343 (MIC approximately 0.7 mg/l), ceftazidime and ceftriaxone. Ten Moraxella str...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 1985-06, Vol.15 Suppl C, p.111-117
Main Authors: Mouton, R P, Mulders, S L, van Gestel, M H
Format: Article
Language:English
Subjects:
Acinetobacter - drug effects
Acinetobacter - enzymology
Anti-Bacterial Agents - pharmacology
beta-Lactamases - metabolism
beta-Lactams
Culture Media
Enterobacteriaceae - drug effects
Enterobacteriaceae - enzymology
Lactams
Microbial Sensitivity Tests
Moraxella - drug effects
Moraxella - enzymology
Neisseria - drug effects
Pseudomonas aeruginosa - drug effects
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Summary:By means of a micro-dilution technique (10(5) cfu/cup) 30 strains of Pseudomonas spp. were found resistant to Sch 34343. The susceptibility of Acinetobacter spp. (20 strains) was greatest for imipenem, followed by Sch 34343 (MIC approximately 0.7 mg/l), ceftazidime and ceftriaxone. Ten Moraxella strains were very susceptible to Sch 34343, imipenem and ceftazidime. For 35 strains of Neisseria gonorrhoeae (ten beta-lactamase-positive) and ten strains of N. meningitidis we noted no resistance to Sch 34343 (MIC 0.015-0.06 mg/l), or to any of the other drugs tested. Sixty-two strains of Enterobacteriaceae producing various beta-lactamases were tested for their sensitivity to Sch 34343 and seven other beta-lactams. To an even greater extent than imipenem and Sch 34343, latamoxef and ceftazidime proved very active against all these strains. A PSE-4-producing Escherichia coli strain was resistant to Sch 34343. The inoculum effect (10(6) vs 10(4) cfu/ml) on Sch 34343 activity was usually small (1-4). Tests for the beta-lactamase susceptibility of Sch 34343 showed that only one PSE-3, one PSE-4 and one chromosomal beta-lactamase from a strain of Enterobacter cloacae were slightly active.
ISSN:0305-7453