Experimental Parvoviral Infection in Humans

Healthy adult volunteers were inoculated intranasally with human parvovirus obtained from an asymptomatic blood donor. One week after inoculation, intense viremia was observed in seronegative volunteers, accompanied by a mild illness with pyrexia, malaise, myalgia, itching, and excretion of virus fr...

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Bibliographic Details
Published in:The Journal of infectious diseases 1985-08, Vol.152 (2), p.257-265
Main Authors: Anderson, M. J., Higgins, P. G., Davis, L. R., Willman, J. S., Jones, S. E., Kidd, I. M., Pattison, J. R., Tyrrell, D. A. J.
Format: Article
Language:English
Subjects:
Anemia, Hemolytic - complications
Antibodies
Biological and medical sciences
Diseases
Exanthema
Female
Hemoglobins - analysis
Human viral diseases
Humans
Infections
Infectious diseases
Inoculation
Leukocyte Count
Male
Medical sciences
Middle Aged
Miscellaneous
Original Articles
Parvoviridae - isolation & purification
Parvoviridae Infections - blood
Parvoviridae Infections - complications
Parvoviridae Infections - etiology
Parvovirus
Platelet Count
Reticulocytes
Symptoms
Time Factors
Tropical viral diseases
Viral cardiopathies
Viral diseases
Viremia
Viremia - etiology
Viruses
Volunteerism
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Summary:Healthy adult volunteers were inoculated intranasally with human parvovirus obtained from an asymptomatic blood donor. One week after inoculation, intense viremia was observed in seronegative volunteers, accompanied by a mild illness with pyrexia, malaise, myalgia, itching, and excretion of virus from the respiratory tract. In the following week hematologic studies revealed reticulocytopenia with an associated slight drop in hemoglobin concentration, lymphopenia, neutropenia, and a drop in platelet counts. At 17–18 days after inoculation a second-phase illness with rash and arthralgia lasting three to four days occurred in three of four infected volunteers. This study confirms the etiologic role of human parvovirus in erythematous rash illness, with the second-phase illness being consistent with adult cases of erythema infectiosum. Moreover, the hematologic changes associated with infection support the hypothesis that the same virus is responsible for the temporary arrest of erythropoiesis that leads to aplastic crisis in persons with chronic hemolytic anemia.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/152.2.257