Relationship between Virion Incidence and Pathological Stage in Virus-induced Leukaemia

SIMILARITIES between leukaemia in mouse and man, together with the unequivocal viral aetiology of the murine disease, have led to the study of murine leukaemia as a model for the human disease. Levine and his associates 1 reported a positive correlation between the clinical status of leukaemic patie...

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Bibliographic Details
Published in:Nature (London) 1969-03, Vol.221 (5183), p.868-869
Main Authors: RICH, MARVIN A, SIEGLER, RICHARD, JOHNS, LEWIS W
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn
Cell Transformation, Neoplastic
Humanities and Social Sciences
letter
Leukemia Virus, Murine - pathogenicity
Leukemia, Experimental - etiology
Leukemia, Lymphoid - etiology
Mice
Microscopy, Electron
multidisciplinary
Science
Science (multidisciplinary)
Thymus Neoplasms - microbiology
Thymus Neoplasms - pathology
Viral Proteins - analysis
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Summary:SIMILARITIES between leukaemia in mouse and man, together with the unequivocal viral aetiology of the murine disease, have led to the study of murine leukaemia as a model for the human disease. Levine and his associates 1 reported a positive correlation between the clinical status of leukaemic patients and the incidence of virus-like particles in their plasma. For future aetiological investigations it seemed necessary to corroborate this finding in a system of known aetiology. Detection of virions by electron microscopy, as well as the isolation of infectious leukaemia virus before development of clinical leukaemia, has been repeatedly demonstrated in mice 2 . Quantitative work on the relationship between virions and the stage of leukaemogenesis has not, however, been reported.
ISSN:0028-0836
1476-4687
DOI:10.1038/221868a0