Ondansetron, an antagonist of 5-HT3 receptors, antagonizes the anti-exploratory effect of caerulein, an agonist of CCK receptors, in the elevated plus-maze

Systemic treatment with caerulein (0.25-5 micrograms/kg SC), non-selective agonist of cholecystokinin (CCK) receptors, dose-dependently suppressed the exploratory behaviour of rats in an elevated plus-maze without producing remarkable changes in the locomotor activity of animals in an open field tes...

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Bibliographic Details
Published in:Psychopharmacologia 1993, Vol.110 (1-2), p.213-218
Main Authors: VASAR, E, PEURANEN, E, ÖÖPIK, T, HARRO, J, MÄNNISTÖ, P. T
Format: Article
Language:English
Subjects:
Animals
Anxiety - psychology
Biological and medical sciences
Ceruletide - antagonists & inhibitors
Ceruletide - pharmacology
Dose-Response Relationship, Drug
Exploratory Behavior - drug effects
Female
Medical sciences
Motor Activity - drug effects
Neuropharmacology
Ondansetron - pharmacology
Pharmacology. Drug treatments
Psycholeptics: tranquillizer, neuroleptic
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Rats
Receptors, Cholecystokinin - agonists
Serotonin Antagonists - pharmacology
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Summary:Systemic treatment with caerulein (0.25-5 micrograms/kg SC), non-selective agonist of cholecystokinin (CCK) receptors, dose-dependently suppressed the exploratory behaviour of rats in an elevated plus-maze without producing remarkable changes in the locomotor activity of animals in an open field test. Ondansetron, a selective antagonist of 5-HT3 receptors, increased the number of open arm entries in the plus-maze test only at a dose 10 micrograms/kg. The other doses of ondansetron (0.1, 1 and 100 micrograms/kg IP) did not significantly change either the locomotor activity or the exploratory behaviour of rats. Pretreatment of rats with ondansetron (at 10 micrograms/kg, but not at 0.1, 1 or 100 micrograms/kg) completely reversed the anti-exploratory effect of caerulein (5 micrograms/kg). The concomitant treatment with caerulein and ondansetron did not cause any major change in the locomotor activity of animals in open field. Consequently, we propose that 5-HT-ergic mechanisms are involved not only in the regulation of CCK release in the cerebral cortex and nucleus accumbens, but also in the modulation of the anti-exploratory effect of caerulein, a CCK agonist, in the elevated plus-maze.
ISSN:0033-3158
1432-2072
DOI:10.1007/BF02246976