Ribonucleic Acid Biosynthesis in Adult and Infant Rat Brain in vitro

The rate of biosynthesis of ribonucleic acid (as judged by the rate of incorporation of uridine into ribonucleic acid) in infant and adult rat brain cortex slices, incubated aerobically in the presence of various substrates, is directly proportional to the adenosine triphosphate concentration. This...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1969-04, Vol.164 (3875), p.79-80
Main Authors: Itoh, T., Quastel, J. H.
Format: Article
Language:English
Subjects:
Acetoacetates - metabolism
Adenosine Triphosphate - metabolism
Adult animals
Age Factors
Animals
Animals, Newborn
Biosynthesis
Brain Chemistry
Carbon Isotopes
Cerebral Cortex - metabolism
Flasks
Glucose - metabolism
Hydroxybutyrates - metabolism
Immatures
In Vitro Techniques
Infants
Rats
RNA
RNA - biosynthesis
Succinates - metabolism
Uracil Nucleotides - analysis
Uridine - metabolism
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Summary:The rate of biosynthesis of ribonucleic acid (as judged by the rate of incorporation of uridine into ribonucleic acid) in infant and adult rat brain cortex slices, incubated aerobically in the presence of various substrates, is directly proportional to the adenosine triphosphate concentration. This suggests that the adenosine triphosphate concentration is one of the factors involved in the control of ribonucleic acid biosynthesis in infant and adult rat brain. Acetoacetate or β -hydroxybutyrate is about 70 percent as effective as glucose, with both infant and adult brain, for the promotion of ribonucleic acid biosynthesis, but they are considerably more effective than succinate in infant brain than in adult brain.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.164.3875.79