Subcortical dopamine and serotonin turnover during acute and subchronic administration of typical and atypical neuroleptics

• Published in: Psychopharmacologia 1993, Vol.110 (1-2), p.145-151
• Main Authors: CSERNANSKY, J. G, WRONA, C. T, BARDGETT, M. E, EARLY, T. S, NEWCOMER, J. W
• Format: Article
• Language: English
• Subjects: Animals; Antipsychotic Agents - pharmacology; Binding, Competitive - drug effects; Biological and medical sciences; Brain Chemistry - drug effects; Dopamine - metabolism; Male; Medical sciences; Neostriatum - drug effects; Neostriatum - metabolism; Neuropharmacology; Nucleus Accumbens - drug effects; Nucleus Accumbens - metabolism; Pharmacology. Drug treatments; Psycholeptics: tranquillizer, neuroleptic; Psychology. Psychoanalysis. Psychiatry; Psychopharmacology; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2 - drug effects; Serotonin - metabolism; Spiperone - pharmacokinetics
• ISSN: 0033-3158; 1432-2072
• DOI: 10.1007/BF02246964

The effects of acute (1 day) and subchronic (28 days) treatment with three atypical antipsychotic drugs [clozapine, (+/-)-sulpiride and (-)-3-PPP] on dopamine and serotonin turnover in both the nucleus accumbens (NA) and corpus striatum (CS) of rodents was compared to haloperidol and saline treatment. The equivalent doses of all drugs were determined based upon their ability to compete in vivo for 3H-spiperone binding in the NA and CS. All three atypical drugs, compared to haloperidol, produced preferential elevations of dopamine turnover in the NA. Further, the development of tolerance of this effect was more apparent for the three atypical drugs than for haloperidol. Surprisingly, all three atypical drugs, but not haloperidol, produced changes in serotonin turnover, despite the fact that (+/-)-sulpiride and (-)-3-PPP have no known direct effects on brain serotonin systems. All three atypical drugs produced acute increases in serotonin turnover in both the NA and CS, followed by later diseases.