Effects of salbutamol upon performance on an operant screen for antidepressants

The beta adrenergic (beta) agonist salbutamol increased reinforcement rates and decreased response rates on a differential-reinforcement-of-low-rate (DRL) 72-S schedule. These changes in DRL 72-S schedule performance are also produced by most clinically used antidepressants. The effects of salbutamo...

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Bibliographic Details
Published in:Psychopharmacologia 1993-11, Vol.113 (1), p.1-10
Main Authors: DUNN, R. T, RICHARDS, J. B, SEIDEN, L. S
Format: Article
Language:English
Subjects:
Albuterol - antagonists & inhibitors
Albuterol - pharmacology
Animals
Antidepressive Agents - pharmacology
Biological and medical sciences
Conditioning, Operant - drug effects
Drug Evaluation, Preclinical
Male
Medical sciences
Methysergide - pharmacology
Metoprolol - pharmacology
Neuropharmacology
Pharmacology. Drug treatments
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Rats
Rats, Sprague-Dawley
Reinforcement Schedule
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Summary:The beta adrenergic (beta) agonist salbutamol increased reinforcement rates and decreased response rates on a differential-reinforcement-of-low-rate (DRL) 72-S schedule. These changes in DRL 72-S schedule performance are also produced by most clinically used antidepressants. The effects of salbutamol on a DRL 72-S schedule were dose-dependently antagonized by the beta antagonist metoprolol, but not changed by the 5HT antagonist methysergide. Additionally, neither salbutamol nor the antagonism of salbutamol by metoprolol caused disruption of DRL 72-S schedule performance. These results indicate that stimulation of beta receptors, and not of 5HT receptors, mediates salbutamol antidepressant-like effects on a DRL 72-S schedule.
ISSN:0033-3158
1432-2072
DOI:10.1007/BF02244325