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Effects of salbutamol upon performance on an operant screen for antidepressants

The beta adrenergic (beta) agonist salbutamol increased reinforcement rates and decreased response rates on a differential-reinforcement-of-low-rate (DRL) 72-S schedule. These changes in DRL 72-S schedule performance are also produced by most clinically used antidepressants. The effects of salbutamo...

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Published in:	Psychopharmacologia 1993-11, Vol.113 (1), p.1-10
Main Authors:	DUNN, R. T, RICHARDS, J. B, SEIDEN, L. S
Format:	Article
Language:	English
Subjects:	Albuterol - antagonists & inhibitors Albuterol - pharmacology Animals Antidepressive Agents - pharmacology Biological and medical sciences Conditioning, Operant - drug effects Drug Evaluation, Preclinical Male Medical sciences Methysergide - pharmacology Metoprolol - pharmacology Neuropharmacology Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Rats Rats, Sprague-Dawley Reinforcement Schedule
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description	The beta adrenergic (beta) agonist salbutamol increased reinforcement rates and decreased response rates on a differential-reinforcement-of-low-rate (DRL) 72-S schedule. These changes in DRL 72-S schedule performance are also produced by most clinically used antidepressants. The effects of salbutamol on a DRL 72-S schedule were dose-dependently antagonized by the beta antagonist metoprolol, but not changed by the 5HT antagonist methysergide. Additionally, neither salbutamol nor the antagonism of salbutamol by metoprolol caused disruption of DRL 72-S schedule performance. These results indicate that stimulation of beta receptors, and not of 5HT receptors, mediates salbutamol antidepressant-like effects on a DRL 72-S schedule.
doi_str_mv	10.1007/BF02244325
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These results indicate that stimulation of beta receptors, and not of 5HT receptors, mediates salbutamol antidepressant-like effects on a DRL 72-S schedule.</description><subject>Albuterol - antagonists & inhibitors</subject><subject>Albuterol - pharmacology</subject><subject>Animals</subject><subject>Antidepressive Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Conditioning, Operant - drug effects</subject><subject>Drug Evaluation, Preclinical</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Methysergide - pharmacology</subject><subject>Metoprolol - pharmacology</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</subject><subject>Psychology. Psychoanalysis. 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Psychiatry</topic><topic>Psychopharmacology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Reinforcement Schedule</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DUNN, R. T</creatorcontrib><creatorcontrib>RICHARDS, J. B</creatorcontrib><creatorcontrib>SEIDEN, L. S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Psychopharmacologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DUNN, R. T</au><au>RICHARDS, J. B</au><au>SEIDEN, L. 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subjects	Albuterol - antagonists & inhibitors Albuterol - pharmacology Animals Antidepressive Agents - pharmacology Biological and medical sciences Conditioning, Operant - drug effects Drug Evaluation, Preclinical Male Medical sciences Methysergide - pharmacology Metoprolol - pharmacology Neuropharmacology Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Rats Rats, Sprague-Dawley Reinforcement Schedule
title	Effects of salbutamol upon performance on an operant screen for antidepressants
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