Intracellular Organic Phosphates as Regulators of Oxygen Release by Haemoglobin

2,3-Diphosphoglycerate is present in the red cells of many species at about equimolar concentration to haemoglobin. It lowers the oxygen affinity and thus facilitates oxygen unloading because it is preferentially bound to deoxyhaemoglobin in the ratio of one mole per tetramer.

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Bibliographic Details
Published in:Nature (London) 1969-02, Vol.221 (5181), p.618-622
Main Authors: BENESCH, REINHOLD, BENESCH, RUTH E
Format: Article
Language:English
Subjects:
Adenosine Triphosphate - blood
Biological Transport
Erythrocytes - metabolism
Fetal Hemoglobin
Glyceric Acids - blood
Glyceric Acids - physiology
Hemoglobins - physiology
Humanities and Social Sciences
Inositol - blood
multidisciplinary
Oxygen - blood
Partial Pressure
Phosphates - blood
Phosphates - physiology
Protein Binding
Science
Science (multidisciplinary)
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Description
Summary:2,3-Diphosphoglycerate is present in the red cells of many species at about equimolar concentration to haemoglobin. It lowers the oxygen affinity and thus facilitates oxygen unloading because it is preferentially bound to deoxyhaemoglobin in the ratio of one mole per tetramer.
ISSN:0028-0836
1476-4687
DOI:10.1038/221618a0