Effects of repeated mild stress and two antidepressant treatments on the behavioral response to 5HT1C receptor activation in rats

This study investigated the possible involvement of 5HT1C receptors in the development of depressive states and in the mode of action of antidepressants. The effects of repeated unpredictable mild stress (a regimen known to induce an anhedonic state in the rat) and of chronic administration of eithe...

Full description

Saved in:
Bibliographic Details
Published in:Psychopharmacologia 1993, Vol.110 (1-2), p.140-144
Main Authors: MOREAU, J.-L, JENCK, F, MARTIN, J. R, PERRIN, S, HAEFELY, W. E
Format: Article
Language:English
Subjects:
Animals
Antidepressive Agents - pharmacology
Behavior, Animal - drug effects
Benzamides - pharmacology
Biological and medical sciences
Depression - physiopathology
Depression - psychology
Dose-Response Relationship, Drug
Male
Medical sciences
Moclobemide
Neuropharmacology
Penile Erection - drug effects
Pharmacology. Drug treatments
Piperazines - pharmacology
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Rats
Rats, Inbred Strains
Receptors, Serotonin - drug effects
Serotonin Receptor Agonists - pharmacology
Sleep Deprivation - physiology
Sleep, REM - physiology
Stress, Psychological - psychology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This study investigated the possible involvement of 5HT1C receptors in the development of depressive states and in the mode of action of antidepressants. The effects of repeated unpredictable mild stress (a regimen known to induce an anhedonic state in the rat) and of chronic administration of either of two recognized antidepressant treatments (sleep deprivation or inhibition of monoamine oxidase type A) in rats were studied on a 5HT1C receptor initiated response, i.e. mCPP-induced penile erection. A 3-week period of repeated, but unpredictable exposure to mild stressors induced a shift to the left of the dose-response curve for mCPP-induced penile erection. In contrast, 72-h REM sleep deprivation resulted in a shift to the right of the mCPP dose-response curve and 10-day administration of the monoamine oxidase type A inhibitor moclobemide (20 mg/kg IP bid) also resulted in a decreased number of mCPP-induced penile erections. These findings support the hypothesis that neuronal activities initiated via 5HT1C receptor stimulation may play a role in the pathophysiology and treatment of depression.
ISSN:0033-3158
1432-2072
DOI:10.1007/BF02246963