Maternal high-fat intake predisposes nonalcoholic fatty liver disease in C57BL/6 offspring

Objective This work aimed to verify the hypothesis that maternal intake of high-fat diet in critical periods of pregnancy and/or suckling period predisposes nonalcoholic fatty liver disease in adult C57BL/6 mice offspring. Study Design Male pups were divided into 5 groups: (1) SC, from standard chow...

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Bibliographic Details
Published in:American journal of obstetrics and gynecology 2010-11, Vol.203 (5), p.495.e1-495.e8
Main Authors: Gregorio, Bianca M., RD, PhD, Souza-Mello, Vanessa, RD, PhD, Carvalho, Jorge J., PhD, Mandarim-de-Lacerda, Carlos A., MD, PhD, Aguila, Marcia B., RD, PhD
Format: Article
Language:English
Subjects:
Alanine Transaminase - metabolism
Alkaline Phosphatase - metabolism
Analysis of Variance
Animals
Blood Glucose
Blotting, Western
Body Weight
Dietary Fats - metabolism
Disease Susceptibility - metabolism
Enzyme-Linked Immunosorbent Assay
fatty liver
Fatty Liver - etiology
Fatty Liver - metabolism
Female
fetal programming
Glucose Tolerance Test
Insulin - blood
Insulin Resistance
Liver - metabolism
liver steatosis
liver ultrastructure
Male
maternal high-fat diet
Maternal Nutritional Physiological Phenomena - physiology
Mice
Obstetrics and Gynecology
Pregnancy
Prenatal Exposure Delayed Effects - metabolism
Radioimmunoassay
Tumor Necrosis Factor-alpha - metabolism
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Summary:Objective This work aimed to verify the hypothesis that maternal intake of high-fat diet in critical periods of pregnancy and/or suckling period predisposes nonalcoholic fatty liver disease in adult C57BL/6 mice offspring. Study Design Male pups were divided into 5 groups: (1) SC, from standard chow–fed dams; (2) G, from high-fat chow (HF)–fed dams during the gestation (G) period; (3) L, from HF-fed dams during the lactation (L) period; (4) GL, from HF-fed dams during the gestation and lactation (GL) periods; and (5) GL/HF, from HF-fed dams during GL, maintaining an HF diet from postweaning to adulthood. We analyzed body mass, plasma blood, and liver structure. Results The G offspring showed insulin resistance and lower glucose transporter-2 expression. Hepatic steatosis was present in the G, L, GL, and mainly in GL/HF offspring. Sterol regulatory element-binding protein-1c expression was higher in G, GL, and GL/HF offspring. Conclusion Programming by HF chow predisposes hepatic adverse remodeling in the liver of adult offspring.
ISSN:0002-9378
1097-6868
DOI:10.1016/j.ajog.2010.06.042