Serum concentrations of monocyte chemoattractant protein-1 in healthy and critically ill dogs

Background: The chemokine monocyte chemoattractant protein‐1 (MCP‐1) is a primary regulator of monocyte mobilization from bone marrow, and increased concentrations of MCP‐1 have been associated with sepsis and other inflammatory disorders in critically ill people. The relationship between MCP‐1 and...

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Published in:Veterinary clinical pathology 2010-09, Vol.39 (3), p.302-305
Main Authors: Duffy, Amanda L., Olea-Popelka, Francisco J., Eucher, James, Rice, Dahlia M., Dow, Steven W.
Format: Article
Language:English
Subjects:
Anemia, Hemolytic - blood
Anemia, Hemolytic - veterinary
Animals
Autoimmune
canine
chemokine
Chemokine CCL2 - blood
chemotaxis
Dog Diseases - blood
Dogs - blood
Enzyme-Linked Immunosorbent Assay - veterinary
Female
Gastroenteritis - blood
Gastroenteritis - veterinary
inflammation
Inflammation - blood
Inflammation - veterinary
Male
monocyte
Parvoviridae Infections - blood
Parvoviridae Infections - veterinary
Postoperative Period
sepsis
Sepsis - blood
Sepsis - veterinary
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Summary:Background: The chemokine monocyte chemoattractant protein‐1 (MCP‐1) is a primary regulator of monocyte mobilization from bone marrow, and increased concentrations of MCP‐1 have been associated with sepsis and other inflammatory disorders in critically ill people. The relationship between MCP‐1 and disease in dogs has not been evaluated previously. Objective: The purpose of this study was to assess serum concentrations of MCP‐1 in healthy dogs, dogs in the postoperative period, and critically ill dogs. We hypothesized that MCP‐1 concentrations would be significantly increased in critically ill dogs compared with postoperative or healthy dogs. Methods: Serum concentrations of MCP‐1 were measured in 26 healthy control dogs, 35 postoperative dogs, and 26 critically ill dogs. Critically ill dogs were further subgrouped into dogs with sepsis, parvovirus gastroenteritis, immune‐mediated hemolytic anemia, and severe trauma (n=26). MCP‐1 concentrations were determined using a commercial canine MCP‐1 ELISA. Associations between MCP‐1 concentrations and disease status were evaluated statistically. Results: MCP‐1 concentration was significantly higher in critically ill dogs (median 578 pg/mL, range 144.7–1723 pg/mL) compared with healthy dogs (median 144 pg/mL, range 4.2–266.8 pg/mL) and postoperative dogs (median 160 pg/mL, range 12.6–560.4 pg/mL) (P
ISSN:0275-6382
1939-165X
DOI:10.1111/j.1939-165X.2010.00228.x